Hoseini Seyed Mehdi, Montazeri Fateme
Biotechnology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran; Hematology and Oncology Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
Tissue Cell. 2025 Apr;93:102709. doi: 10.1016/j.tice.2024.102709. Epub 2024 Dec 31.
Mesenchymal stem cells (MSCs) have several important properties that make them desirable for regenerative medicine. These properties include immunomodulatory ability, growth factor production, and differentiation into various cell types. Despite extensive research and promising results in clinical trials, our understanding of MSC biology, their mechanism of action, and their targeted and routine use in clinics is limited. Differentiation of human MSCs (hMSCs) is a complex process influenced by various elements such as growth factors, pharmaceutical compounds, microRNAs, 3D scaffolds, and mechanical and electrical stimulation. Research has shown that different culture conditions can affect the differentiation potential of hMSCs obtained from multiple fetal and adult sources. Additionally, it seems that what affects the differentiation capacities of these cells is their secretory characteristics, which are influenced by the origin of the cells and the local microenvironment where the cells are located. The review can provide insights into the microenvironment-based mechanisms involved in MSC differentiation, which can be valuable for future therapeutic applications.
间充质干细胞（MSCs）具有多种重要特性，使其在再生医学领域备受青睐。这些特性包括免疫调节能力、生长因子分泌以及向多种细胞类型分化的能力。尽管在临床试验中进行了广泛研究并取得了令人鼓舞的结果，但我们对MSCs生物学、其作用机制以及在临床中的靶向和常规应用的了解仍然有限。人MSCs（hMSCs）的分化是一个复杂的过程，受到多种因素的影响，如生长因子、药物化合物、微小RNA、3D支架以及机械和电刺激。研究表明，不同的培养条件会影响从多个胎儿和成人来源获得的hMSCs的分化潜能。此外，似乎影响这些细胞分化能力的是它们的分泌特性，而分泌特性又受到细胞来源和细胞所处局部微环境的影响。这篇综述可以深入了解基于微环境的MSCs分化机制，这对于未来的治疗应用可能具有重要价值。
