神经退行性疾病中的RNA甲基化修饰：聚焦于其酶系统。

RNA methylation modifications in neurodegenerative diseases: Focus on their enzyme system.

作者信息

Liu Lu, Zhao Yu-Jia, Zhang Feng

机构信息

Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education and Key Laboratory of Basic Pharmacology of Guizhou Province and Laboratory Animal Centre, Zunyi Medical University, Zunyi, Guizhou, China.

出版信息

J Adv Res. 2025 Jan 5. doi: 10.1016/j.jare.2025.01.008.

DOI:10.1016/j.jare.2025.01.008

PMID:39765326

Abstract

BACKGROUND

Neurodegenerative diseases (NDs) constitute a significant public health challenge, as they are increasingly contributing to global mortality and morbidity, particularly among the elderly population. Pathogenesis of NDs is intricate and multifactorial. Recently, post-transcriptional modifications (PTMs) of RNA, with a particular focus on mRNA methylation, have been gaining increasing attention. At present, several regulatory genes associated with mRNA methylation have been identified and closely associated with neurodegenerative disorders.

AIM OF REVIEW

This review aimed to summarize the RNA methylation enzymes system, including the writer, reader, and eraser proteins and delve into their functions in the central nervous system (CNS), hoping to open new avenues for exploring the mechanisms and therapeutic strategies for NDs.

KEY SCIENTIFIC CONCEPTS OF REVIEW

Recently, studies have highlighted the critical role of RNA methylation in the development and function of the CNS, and abnormalities in this process may contribute to brain damage and NDs, aberrant expression of enzymes involved in RNA methylation has been implicated in the onset and development of NDs.

摘要

背景

神经退行性疾病（NDs）是一项重大的公共卫生挑战，因为它们对全球死亡率和发病率的影响日益增加，尤其是在老年人群中。NDs的发病机制复杂且具有多因素性。最近，RNA的转录后修饰（PTMs），尤其是mRNA甲基化，受到了越来越多的关注。目前，已鉴定出几个与mRNA甲基化相关的调控基因，且它们与神经退行性疾病密切相关。