Wang Wanying, Luo Fucheng
State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, 650500, Yunnan, China.
Sheng Wu Gong Cheng Xue Bao. 2023 Jan 25;39(1):45-59. doi: 10.13345/j.cjb.220236.
There are a variety of post-transcriptional modifications in mRNA, which regulate the stability, splicing, translation, transport and other processes of mRNA, followed by affecting cell development, body immunity, learning and cognition and other important physiological functions. mA modification is one of the most abundant post-transcriptional modifications widely existing in mRNA, regulating the metabolic activities of RNA and affecting gene expression. mA modified homeostasis is critical for the development and maintenance of the nervous system. In recent years, mA modification has been found in neurodegenerative diseases, mental diseases and brain tumors. This review summarizes the role of mA methylation modification in the development, function and related diseases of the central nervous system in recent years, providing potential clinical therapeutic targets for neurological diseases.
信使核糖核酸（mRNA）存在多种转录后修饰，这些修饰可调控mRNA的稳定性、剪接、翻译、转运等过程，进而影响细胞发育、机体免疫、学习与认知等重要生理功能。N6-甲基腺嘌呤（mA）修饰是广泛存在于mRNA中的最丰富的转录后修饰之一，可调控RNA的代谢活动并影响基因表达。mA修饰稳态对于神经系统的发育和维持至关重要。近年来，在神经退行性疾病、精神疾病和脑肿瘤中均发现了mA修饰。本文综述了近年来mA甲基化修饰在中枢神经系统发育、功能及相关疾病中的作用，为神经疾病提供了潜在的临床治疗靶点。
