Ahmad Mohd Faizal, Elias Marjanu Hikmah, Mat Jin Norazilah, Abu Muhammad Azrai, Syafruddin Saiful Effendi, Zainuddin Ani Amelia, Suzuki Nao, Abdul Karim Abdul Kadir
Advanced Reproductive Centre (ARC) HCTM UKM, Department of Obstetrics & Gynecology, Faculty of Medicine, National University of Malaysia, Jalan Yaacob Latiff, Cheras, Kuala Lumpur 56000, Malaysia.
Faculty of Medicine & Health Sciences, Universiti Sains Islam Malaysia, Nilai 71800, Malaysia.
Biology (Basel). 2024 Nov 26;13(12):978. doi: 10.3390/biology13120978.
An overall in vitro fertilization (IVF) outcome is dynamic. Good oocyte quality is important for achieving a better IVF pregnancy. Various methods have been used for OQ assessment (OQA). However, due to inconclusive evidence, one method's superiority has not been proposed over others. Thus, OQA should be consolidated based on the current evidence for this matter. Our study aims to summarize the current OQA used and compare their recommended methods. Our results revealed that the optimal OQA for cost-effectiveness and clinical implementation is still via morphological assessment. The current method most opted for is total oocyte scoring. Although other methods-follicular fluid evaluation, mitochondria spindle assessment, or live zona imaging-can be applied with better precision, due to cost, additional tools, and expertise, and they should cater to research purposes and selected centers. Our results added value as a current strategy for optimizing OQA in IVF practice, aiming at cost-effectiveness and reproducibility for better clinical implementation.
体外受精（IVF）的总体结果是动态变化的。优质的卵母细胞质量对于实现更好的IVF妊娠结局至关重要。已采用多种方法进行卵母细胞质量评估（OQA）。然而，由于证据不确凿，尚未有哪种方法被认为比其他方法更具优越性。因此，应基于当前关于此事的证据来整合OQA。我们的研究旨在总结当前使用的OQA方法并比较其推荐方法。我们的结果表明，从成本效益和临床应用角度来看，最佳的OQA方法仍是形态学评估。目前最常采用的方法是对卵母细胞进行全面评分。虽然其他方法——卵泡液评估、线粒体纺锤体评估或活态透明带成像——可以更精确地应用，但由于成本、额外工具和专业知识的要求，它们应主要用于研究目的和特定中心。我们的研究结果为优化IVF实践中的OQA提供了一种当前策略，旨在实现成本效益和可重复性，以更好地应用于临床。
