Al-Mansour Mubarak, Aga Syed Sameer, O'Connor Owen A
Adult Medical Oncology, Princess Noorah Oncology Centre, Ministry of National Guard Health Affairs-Western Region (MNGHA-WR), King Saud Bin Abdul Aziz University for Health Sciences (KSAU-HS), King Abdullah International Medical Research Centre (KAIMRC), King Abdulaziz Medical City, Jeddah 21423, Saudi Arabia.
College of Medicine, King Abdullah International Medical Research Centre (KAIMRC), King Saud Bin Abdul Aziz University for Health Sciences (KSAU-HS), Ministry of National Guard Health Affairs-Western Region (MNGHA-WR), King Abdulaziz Medical City, Jeddah 21423, Saudi Arabia.
Cancers (Basel). 2024 Dec 11;16(24):4131. doi: 10.3390/cancers16244131.
T-cell lymphomas (TCLs) are rare and aggressive malignancies associated with poor outcomes, often because of the development of acquired drug resistance as well as intolerance to the established and often toxic chemotherapy regimens in elderly and frail patients. The many subtypes of TCL are well established to exhibit marked geographic variation. The epidemiology, clinical presentation, diagnosis, prognosis, and treatment of TCLs in the Middle East (ME) are yet to be explored; hence, limited data are available about these entities in this part of the world. : Therefore, in this review article, we aim to discuss the available data regarding the T-cell neoplasms in the ME, including the incidence of specific subtypes of peripheral T-cell lymphoma (PTCL), as well as the trends in survival and treatment, all in an effort to understand the natural history of these complex entities across the ME.
T细胞淋巴瘤（TCLs）是罕见的侵袭性恶性肿瘤，预后较差，这通常是由于获得性耐药的出现，以及老年和体弱患者对既定的、往往具有毒性的化疗方案不耐受。TCL的许多亚型已被充分证实存在显著的地理差异。中东地区（ME）TCLs的流行病学、临床表现、诊断、预后和治疗尚未得到研究；因此，关于世界这一地区这些疾病实体的数据有限。因此，在这篇综述文章中，我们旨在讨论中东地区T细胞肿瘤的现有数据，包括外周T细胞淋巴瘤（PTCL）特定亚型的发病率，以及生存和治疗趋势，所有这些都是为了了解这些复杂疾病实体在中东地区的自然史。
