Brender J D, Marcuse E K, Weiss N S, Koepsell T D
Am J Dis Child. 1985 Apr;139(4):338-40. doi: 10.1001/archpedi.1985.02140060020016.
Family history of appendicitis was studied in 135 children with histologic confirmation of acute appendicitis and in 212 control children without appendicitis, matched by age, sex, and admission date. Parents of patients with appendicitis were approximately 10% more likely than parents of control children to have a positive history of this disease, a difference that could have easily arisen by chance. In contrast, seven patients with appendicitis had siblings with a history of appendicitis, whereas only 0.64 would have been expected on the basis of the proportion among the control group. A significant positive trend was also noted between the proportion of family members with a history of appendicitis and risk for this disease in children. These results indicate some familial tendency for appendicitis, although not to the extent suggested by previous studies.
对135名经组织学确诊为急性阑尾炎的儿童以及212名无阑尾炎的对照儿童进行了阑尾炎家族史研究，这些对照儿童在年龄、性别和入院日期方面进行了匹配。阑尾炎患者的父母有这种疾病阳性家族史的可能性比对照儿童的父母高约10%，这种差异很可能是偶然出现的。相比之下，7名阑尾炎患者有患阑尾炎病史的兄弟姐妹，而根据对照组中的比例，预计只有0.64人会出现这种情况。在有阑尾炎病史的家庭成员比例与儿童患这种疾病的风险之间也发现了显著的正相关趋势。这些结果表明阑尾炎存在一定的家族倾向，尽管程度不如先前研究所暗示的那样。
