Šovljanski Olja, Aćimović Milica, Cvanić Teodora, Travičić Vanja, Popović Aleksandra, Vulić Jelena, Ćetković Gordana, Ranitović Aleksandra, Tomić Ana
Faculty of Technology Novi Sad, University of Novi Sad, Bulevar Cara Lazara 1, 21000 Novi Sad, Serbia.
Institute of Field and Vegetable Crops Novi Sad, Maksima Gorkog 30, 21000 Novi Sad, Serbia.
Antibiotics (Basel). 2024 Dec 4;13(12):1178. doi: 10.3390/antibiotics13121178.
This study explores the bioactive properties of extracts obtained from Robin's pincushion () collected in Sokobanja, Serbia. Comprehensive in vitro assessments reveal high concentrations of total phenolics (186.37 mg GAE/g), along with significant levels of carotenoids (44.10 μg β-car/g). Robin's pincushion exhibited superior antioxidant capacities across DPPH, ABTS, and reducing power assays, significantly outperforming comparable extracts from rosehip () and black rosehip () in these activities. Additionally, high inhibitory effects were observed in antimicrobial assays, with the extract demonstrating minimal inhibitory concentrations (MIC) as low as 1.56 mg/mL against the species. Notably, the extract achieved full bactericidal effect within 24 h in time-kill kinetic studies which additionally highlight its potent antistaphylococcal potential. Analyzing their phytochemical profiles and evaluating their potential as antioxidant, anti-inflammatory, antihyperglycemic, and antimicrobial agents, wide-ranging evaluation of bioactivity of Robin's pincushion was conducted. These findings highlight Robin's pincushion as a promising natural source of bioactive compounds with potential applications in traditional and modern medicine for managing oxidative stress, inflammation, hyperglycemia, and microbial infections.
本研究探索了从塞尔维亚索科巴尼亚采集的针垫花（）提取物的生物活性特性。全面的体外评估显示，其总酚含量高（186.37毫克没食子酸当量/克），类胡萝卜素水平也显著（44.10微克β-胡萝卜素/克）。在DPPH、ABTS和还原力测定中，针垫花表现出卓越的抗氧化能力，在这些活性方面显著优于玫瑰果（）和黑玫瑰果（）的同类提取物。此外，抗菌测定中观察到高抑制作用，该提取物对该物种显示出低至1.56毫克/毫升的最低抑菌浓度（MIC）。值得注意的是，在时间-杀菌动力学研究中，该提取物在24小时内达到了完全杀菌效果，这进一步突出了其强大的抗葡萄球菌潜力。通过分析其植物化学特征并评估其作为抗氧化、抗炎、抗高血糖和抗菌剂的潜力，对针垫花的生物活性进行了广泛评估。这些发现突出了针垫花作为生物活性化合物的有前景的天然来源，在传统医学和现代医学中对于管理氧化应激、炎症、高血糖和微生物感染具有潜在应用价值。
