Province M A, Rao D C
Am J Hum Genet. 1985 Jan;37(1):178-92.
A multifactorial model incorporating temporal trends in its parameters is discussed. The model is a generalization of the tau model of Rice et al. in which the parameters are assumed to be specific functions of time. A special case of this model is fit to data on height, weight, and Quetelet index in 1,067 nuclear families to demonstrate the utility of the approach. The results indicate that there is considerable temporal variation in family resemblance over time for all three traits. For height and Quetelet index, both the transmissibility, comparable to heritability, and residual sibling environmental correlation show temporal changes, while for weight, only the latter exhibits significant trends. Trends were not found in the marital correlation for any of the traits, and only limited evidence was found for trends in the maternal transmission parameter for height. This provides an objective method for evaluating the nature and sources of temporal trends in family resemblance, which can easily be incorporated into the framework of any model-based approach.
讨论了一种在其参数中纳入时间趋势的多因素模型。该模型是Rice等人的tau模型的推广,其中参数被假定为时间的特定函数。将此模型的一个特殊情况应用于1067个核心家庭的身高、体重和克托莱指数数据,以证明该方法的实用性。结果表明,所有这三个性状的家庭相似性随时间存在相当大的时间变化。对于身高和克托莱指数,与遗传力相当的传递性以及同胞残余环境相关性均显示出时间变化,而对于体重,只有后者呈现出显著趋势。在任何性状的婚姻相关性中均未发现趋势,并且仅发现有限的证据表明身高的母体传递参数存在趋势。这提供了一种评估家庭相似性时间趋势的性质和来源的客观方法,该方法可以很容易地纳入任何基于模型的方法框架中。