Lee Ki Won, Xu Guangpeng, Paik Dong Hyun, Shim Youn Young, Reaney Martin J T, Park Ilbum, Lee Sang-Hun, Park Jong-Yul, Park Euddeum, Lee Sung-Bum, Kim In Ah, Hong Ji Youn, Kim Young Jun
Natural Products Convergence R&D Division, Kwangdong Pharmaceutical Co., Ltd., Gwacheon 13840, Republic of Korea.
Department of Food and Biotechnology, Korea University, Sejong 30019, Republic of Korea.
Foods. 2024 Dec 12;13(24):4021. doi: 10.3390/foods13244021.
Alcohol consumption is associated with both short- and long-term adverse effects, including hangover symptoms. The objective of this study was to examine the potential benefits of traditional beverages containing a combination of extract (HD) with either extract (HDPB) or glutathione yeast extract (HDGB) in abbreviating alcohol intoxication and mitigating hangover symptoms. A total of 25 participants between the ages of 19 and 40 who had previously experienced a hangover were evaluated in a randomized, double-blind, crossover, placebo (PLA)-controlled clinical trial. Results showed that lower blood alcohol concentrations in the HDPB and HDGB groups were significantly lower than in the PLA group at 0.25 and 0.5 h, suggesting that HD aids in early alcohol metabolism (0 h, < 0.05). Analysis of the hourly Acute Hangover Scale (AHS) showed that all treatment groups had significantly reduced gastrointestinal disorder symptoms compared to the PLA group ( < 0.05). It can be confirmed that hangover symptoms can be significantly improved by consuming HD combination drinks, apart from the effect of reducing blood alcohol and acetaldehyde concentrations. Therefore, it is predicted that the consumption of natural phytochemicals added to HD is safe for humans and may help accelerate recovery from hangover symptoms.
饮酒与短期和长期的不良影响相关，包括宿醉症状。本研究的目的是检验含有水飞蓟宾提取物（HD）与水飞蓟宾磷脂酰胆碱提取物（HDPB）或谷胱甘肽酵母提取物（HDGB）组合的传统饮料在缩短酒精中毒时间和减轻宿醉症状方面的潜在益处。在一项随机、双盲、交叉、安慰剂（PLA）对照的临床试验中，对25名年龄在19至40岁之间且曾有过宿醉经历的参与者进行了评估。结果显示，在0.25小时和0.5小时时，HDPB组和HDGB组的血液酒精浓度显著低于PLA组，表明HD有助于早期酒精代谢（0小时，P<0.05）。对每小时急性宿醉量表（AHS）的分析表明，与PLA组相比，所有治疗组的胃肠道紊乱症状均显著减轻（P< 0.05）。可以确认，除了降低血液酒精和乙醛浓度的作用外，饮用HD组合饮料可显著改善宿醉症状。因此，预计添加到HD中的天然植物化学物质对人类是安全的，并且可能有助于加速从宿醉症状中恢复。
