Barak Timur Hakan, Kurt-Celep İnci, Celep Engin
Department of Pharmacognosy, Faculty of Pharmacy, Acibadem Mehmet Ali Aydınlar University, Ataşehir, İstanbul 34752, Türkiye.
Department of Biotechnology, Faculty of Pharmacy, İstanbul Okan University, Tuzla, İstanbul 34940, Türkiye.
Foods. 2024 Dec 18;13(24):4092. doi: 10.3390/foods13244092.
Various species from the genus are recorded as food and folk medicine against both kidney complications and diabetes. Ehrh. is documented as a folk remedy in Türkiye against several kidney disorders. This study was designed to evaluate the possible protective mechanisms of EtOH extract (ETE) against kidney disorders and diabetes through different routes, such as the prevention of ROS formation, inhibitory potential against various DM-related enzymes, and a reduction in the amount of the mediators leading to disorders in both systems at the cellular level. The objective was to achieve advanced precision for in vitro results while considering the effect of GIS on oral consumption. Both phytochemical and bioactivity studies were conducted before and after simulated digestion. The results showed that ETE is a rich source of flavonoids and phenolic acids. In addition, it has significant antioxidant and enzyme inhibitory potential. Treatment also yielded promising results at the cellular level for both antioxidative and inhibitor proteins, which may play a role in the pathogenesis of kidney disorders and diabetes. Following the in vitro digestion procedure, both the number of phytochemical ingredients and bioactivity parameters showed a considerable decreasing trend; however, the results are still significant enough to justify the traditional utilization of the genus . This investigation demonstrated that ETE has noteworthy potential as a functional food for protection against diabetic kidney disease.
该属的多种植物被记载可作为食物和民间药物,用于治疗肾脏并发症和糖尿病。Ehrh.在土耳其被记载为治疗多种肾脏疾病的民间疗法。本研究旨在评估[植物名称]乙醇提取物(ETE)通过不同途径预防肾脏疾病和糖尿病的可能保护机制,如预防活性氧形成、对各种糖尿病相关酶的抑制潜力,以及在细胞水平上减少导致两个系统紊乱的介质数量。目的是在考虑地理信息系统对口服消费的影响的同时,实现体外结果的高精度。在模拟消化前后进行了植物化学和生物活性研究。结果表明,ETE是黄酮类化合物和酚酸的丰富来源。此外,它具有显著的抗氧化和酶抑制潜力。该提取物在细胞水平上对抗氧化和抑制蛋白也产生了有前景的结果,这些蛋白可能在肾脏疾病和糖尿病的发病机制中起作用。经过体外消化程序后,植物化学成分的数量和生物活性参数均呈现出相当大的下降趋势;然而,结果仍然具有足够的显著性,足以证明该属植物传统用途的合理性。这项研究表明,ETE作为预防糖尿病肾病的功能性食品具有显著潜力。