Fang Ku-Hao, Lo Sheng-Wei, Kudva Adarsh, De Vito Andrea, Tsai Yuan-Hsiung, Hsu Cheng-Ming, Chang Geng-He, Huang Ethan I, Tsai Ming-Shao, Lai Chia-Hsuan, Tsai Ming-Hsien, Liao Chun-Ta, Kang Chung-Jan, Tsai Yao-Te
Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Taoyuan 333423, Taiwan.
College of Medicine, Chang Gung University, Taoyuan 330036, Taiwan.
Diagnostics (Basel). 2024 Dec 19;14(24):2856. doi: 10.3390/diagnostics14242856.
BACKGROUND/OBJECTIVES: Chronic inflammation significantly contributes to human malignancies. We investigated the prognostic significance of the preoperative modified systemic inflammation score (mSIS) in patients with primary oral cavity squamous cell carcinoma (OCSCC).
We retrospectively reviewed data from 320 OCSCC patients who underwent curative surgery between 2007 and 2017. Based on preoperative lymphocyte-to-monocyte ratio (LMR) and serum albumin levels, patients were classified into three groups: mSIS = 2 (LMR < 3.4 and albumin < 4.0 g/dL), mSIS = 1 (LMR < 3.4 or albumin < 4.0 g/dL), and mSIS = 0 (LMR ≥ 3.4 and albumin ≥ 4.0 g/dL). We explored the associations between the preoperative mSIS and overall survival (OS) and disease-free survival (DFS). We developed a nomogram based on mSIS for OS prediction.
The distribution was mSIS = 0 ( = 197, 61.6%), mSIS = 1 ( = 99, 30.9%), and mSIS = 2 ( = 24, 7.5%). Kaplan-Meier estimated OS and DFS for the mSIS = 0, mSIS = 1, and mSIS = 2 groups demonstrated a sequential decrease (both < 0.001). The prognostic significance of mSIS was consistent across subgroup analyses. Multivariable analysis revealed that mSIS = 1 and mSIS = 2 were independent negative prognostic indicators. The mSIS-based nomogram effectively predicted OS (concordance index: 0.755).
The mSIS reliably predicts OS and DFS in OCSCC patients undergoing surgery, with the nomogram providing individualized OS estimates, enhancing mSIS's clinical utility.
背景/目的：慢性炎症在人类恶性肿瘤的发生中起着重要作用。我们研究了术前改良全身炎症评分（mSIS）对原发性口腔鳞状细胞癌（OCSCC）患者的预后意义。
我们回顾性分析了2007年至2017年间接受根治性手术的320例OCSCC患者的数据。根据术前淋巴细胞与单核细胞比值（LMR）和血清白蛋白水平，将患者分为三组：mSIS = 2（LMR < 3.4且白蛋白 < 4.0 g/dL），mSIS = 1（LMR < 3.4或白蛋白 < 4.0 g/dL），mSIS = 0（LMR ≥ 3.4且白蛋白 ≥ 4.0 g/dL）。我们探讨了术前mSIS与总生存期（OS）和无病生存期（DFS）之间的关联。我们基于mSIS开发了一种列线图用于OS预测。
分布情况为mSIS = 0（n = 197，61.6%），mSIS = 1（n = 99，30.9%），mSIS = 2（n = 24，7.5%）。Kaplan-Meier法估计的mSIS = 0、mSIS = 1和mSIS = 2组的OS和DFS呈依次下降趋势（均P < 0.001）。mSIS的预后意义在亚组分析中是一致的。多变量分析显示mSIS = 1和mSIS = 2是独立的阴性预后指标。基于mSIS的列线图能有效预测OS（一致性指数：0.755）。
mSIS能可靠地预测接受手术的OCSCC患者的OS和DFS，列线图可提供个性化的OS估计，提高了mSIS的临床应用价值。
