Gawęcki Maciej, Kiciński Krzysztof, Kucharczuk Jan, Teper Sławomir, Hubert Magdalena, Kuc Tomasz
Department of Ophthalmology, Pomeranian Hospitals, 84-200 Wejherowo, Poland.
Dobry Wzrok Ophthalmological Center, 80-392 Gdansk, Poland.
Diagnostics (Basel). 2024 Dec 20;14(24):2868. doi: 10.3390/diagnostics14242868.
Ultra-wide-field optical coherence tomography (UWF-OCT) devices have recently been introduced to clinical practice. The goal of this study was to compare choroidal and retinal thickness (CT and RT) in age-related macular degeneration (AMD) with a healthy control group using UWF-OCT Xephilio S1. Additionally, we sought to determine the relationship between the RT and CT of patients with AMD, measured in different sectors, and their visual acuity.
The study included 104 eyes from 74 participants with dry AMD, 119 eyes from 86 participants with wet AMD, and 85 eyes from 53 healthy controls. Of the participants with wet AMD, 87 eyes received anti-VEGF treatment, 13 were treatment naïve, and 19 had incomplete data. The analyzed measurements were taken in the central area of 3 mm in diameter and two peripheral rings located between 3-9 mm and 9-18 mm diameters.
There was no significant variation in the RT in any sector between the three study groups. CT in dry and wet AMD cohorts was significantly lower compared to controls in every sector. Patients with treatment-naïve wet AMD did not demonstrate significant CT loss but had a tendency for lower CT values. Visual impairment in patients with AMD correlated with older age in both subgroups and with smaller RT in the dry AMD subgroup.
Values of RT and CT obtained at the mid- and far-periphery with UWF-OCT generally reflect the alterations observed in AMD in the central part of the posterior pole. Intravitreal anti-VEGF treatment might contribute to loss of choroidal tissue observed in AMD in every sector.
超广角光学相干断层扫描（UWF-OCT）设备最近已引入临床实践。本研究的目的是使用UWF-OCT Xephilio S1比较年龄相关性黄斑变性（AMD）患者与健康对照组的脉络膜和视网膜厚度（CT和RT）。此外，我们试图确定AMD患者在不同扇形区域测量的RT和CT之间的关系及其视力。
本研究纳入了74名干性AMD参与者的104只眼、86名湿性AMD参与者的119只眼以及53名健康对照者的85只眼。在湿性AMD参与者中，87只眼接受了抗VEGF治疗，13只眼未接受过治疗，19只眼数据不完整。分析的测量值在直径3mm的中心区域以及位于直径3-9mm和9-18mm之间的两个外周环中进行。
三个研究组之间在任何扇形区域的RT均无显著差异。干性和湿性AMD队列中各扇形区域的CT均显著低于对照组。未接受过治疗的湿性AMD患者未表现出显著的CT损失，但有CT值较低的趋势。AMD患者的视力损害在两个亚组中均与年龄较大相关，在干性AMD亚组中与较小的RT相关。
使用UWF-OCT在中周部和远周部获得的RT和CT值通常反映了后极部中央区域AMD中观察到的改变。玻璃体内抗VEGF治疗可能导致AMD各扇形区域观察到的脉络膜组织损失。
