Clarke E A, Hatcher J, McKeown-Eyssen G E, Lickrish G M
Am J Obstet Gynecol. 1985 Mar 1;151(5):612-6. doi: 10.1016/0002-9378(85)90149-8.
Information on possible risk factors of cervical dysplasia, including indices of sexual behavior, smoking habits, and the use of oral contraceptives was obtained from a case-control study in Ontario in which 250 cases of histologically proved cervical dysplasia and 500 age-matched neighborhood controls were interviewed. Initial analysis showed an increased risk associated with more than one sexual partner, an early age at first intercourse, current smoking, the use and duration of use of oral contraceptives, and education. However, the increased risk of use and duration of use of oral contraceptives and education was reduced after adjustment for indices of sexual behavior and smoking. This finding does not confirm previously reported large adverse effects of pill use. The relationship between smoking and cervical dysplasia might be explained by some agent in cigarette smoke which depresses the immune mechanism, thus permitting a sexually transmitted agent to result in abnormal cellular development that leads to the onset of cervical dysplasia.
关于宫颈发育异常可能的风险因素的信息，包括性行为指标、吸烟习惯和口服避孕药的使用情况，来自安大略省的一项病例对照研究，该研究对250例经组织学证实的宫颈发育异常病例和500名年龄匹配的社区对照进行了访谈。初步分析显示，多个性伴侣、初次性交年龄早、当前吸烟、口服避孕药的使用及使用时长以及受教育程度与风险增加相关。然而，在对性行为指标和吸烟情况进行调整后，口服避孕药的使用及使用时长和受教育程度导致的风险增加有所降低。这一发现并未证实先前报道的口服避孕药的大量不良影响。吸烟与宫颈发育异常之间的关系可能是由香烟烟雾中的某种物质所解释的，这种物质会抑制免疫机制，从而使性传播病原体导致异常细胞发育，进而引发宫颈发育异常。
