Trevathan E, Layde P, Webster L A, Adams J B, Benigno B B, Ory H
JAMA. 1983;250(4):499-502.
We conducted a case-control study of cigarette smoking and dysplasia and carcinoma in situ of the uterine cervix. Cases were black women 17 to 55 years of age who were attending a dysplasia clinic and had biopsy-confirmed cervical pathologic conditions. Controls were women who were attending the family planning clinic at the same hospital and who had at least two normal Papanicolaou smears. Results were adjusted for age, number of sexual partners, age at first intercourse, socioeconomic status, and oral contraceptive use. Cigarette smoking was significantly associated with carcinoma in situ, severe dysplasia, and mild-moderate dysplasia (relative risks, 3.6, 3.3, and 2.4, respectively). Cumulative exposure to cigarette smoking (as measured by pack-years smoked) was strongly related to the risk of these conditions; women with 12 or more pack-years of exposure had relative risks of 12.7, 10.2, and 4.3, respectively, for the three conditions. There was some evidence that the risk was greatest in women who began smoking in their early teenage years. A reduction in the risk of cervical cancer appears to be another inducement for young women not to smoke.
我们开展了一项关于吸烟与子宫颈发育异常及原位癌的病例对照研究。病例为年龄在17至55岁之间、前往发育异常门诊就诊且活检确诊患有宫颈病理疾病的黑人女性。对照为在同一家医院计划生育门诊就诊且至少有两次巴氏涂片检查结果正常的女性。对结果进行了年龄、性伴侣数量、首次性交年龄、社会经济地位和口服避孕药使用情况的校正。吸烟与原位癌、重度发育异常以及轻度至中度发育异常显著相关（相对风险分别为3.6、3.3和2.4）。吸烟的累积暴露量（以吸烟包年数衡量）与这些疾病的风险密切相关；暴露于12个或更多吸烟包年的女性，这三种疾病的相对风险分别为12.7、10.2和4.3。有证据表明，在青少年早期开始吸烟的女性中风险最大。宫颈癌风险的降低似乎是年轻女性不吸烟的另一个诱因。
