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（Thunb.）Siebold叶提取物的生物活性评价与植物化学特征分析

Bioactivity Evaluation and Phytochemical Characterization of (Thunb.) Siebold Leaf Extract.

作者信息

Yoon Won-Joo, Min Hye-Ji, Cho Hyun-Dong, Kim Hwi-Gon, Park Wool-Lim, Kim Du-Hyun, Tachibana Hirofumi, Seo Kwon-Il

机构信息

Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan.

Department of Food Biotechnology, Dong-A University, Busan 49315, Republic of Korea.

出版信息

Biomedicines. 2024 Dec 23;12(12):2928. doi: 10.3390/biomedicines12122928.

DOI:10.3390/biomedicines12122928
PMID:39767833
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11673389/
Abstract

BACKGROUND

() has traditionally been used for medicinal purposes, and its leaves are considered edible. While is known for its diverse biological activities, the antioxidant, antidiabetic, and anticancer effects of its leaves extracted using different solvents have not been thoroughly investigated.

METHODS

This study examined the antioxidant, antidiabetic, anticancer, and life-prolonging effects of () leaf extract.

RESULTS

The phytochemical analysis showed that the ethanol extract contained the highest levels of polyphenols (347.2 mg/mL) and flavonoids (317.7 mg/mL) compared to the water and methanol extracts. In addition, specific phenolics, such as rutin, ellagic acid, and quercetin, were found in the ethanol extract. Antioxidant assays showed that the ethanol extract exhibited superior DPPH, ABTS radical, and HO-scavenging activities, as well as reducing power. In addition, the ethanol extract displayed strong α-glucosidase inhibitory activity in a dose-dependent manner. In cancer cell studies, the ethanol extract selectively inhibited the proliferation of MDA-MB-231 (breast) and LNCaP (prostate) cancer cells without affecting normal cells. Apoptosis induction was confirmed by nuclear condensation and increased caspase-3 activity. Furthermore, treatment with 30 mg/kg/day of the extract extended the lifespan of the tumor-bearing mice to 50 days, with no fatalities, indicating a dose-dependent protective effect.

CONCLUSIONS

leaf ethanol extract has potential as an antioxidant, antidiabetic, anticancer, and life-prolonging agent.

摘要

背景

（）传统上一直用于药用，其叶子被认为可食用。虽然（）以其多样的生物活性而闻名，但其使用不同溶剂提取的叶子的抗氧化、抗糖尿病和抗癌作用尚未得到充分研究。

方法

本研究检测了（）叶提取物的抗氧化、抗糖尿病、抗癌和延长寿命的作用。

结果

植物化学分析表明，与水提取物和甲醇提取物相比，乙醇提取物中多酚（347.2毫克/毫升）和黄酮类化合物（317.7毫克/毫升）的含量最高。此外，在乙醇提取物中还发现了特定的酚类物质，如芦丁、鞣花酸和槲皮素。抗氧化试验表明，乙醇提取物表现出优异的DPPH、ABTS自由基和HO清除活性以及还原能力。此外，乙醇提取物以剂量依赖的方式表现出较强的α-葡萄糖苷酶抑制活性。在癌细胞研究中，乙醇提取物选择性抑制MDA-MB-231（乳腺癌）和LNCaP（前列腺癌）癌细胞的增殖，而不影响正常细胞。通过核浓缩和caspase-3活性增加证实了细胞凋亡诱导。此外，以30毫克/千克/天的提取物处理将荷瘤小鼠的寿命延长至50天，无死亡情况，表明具有剂量依赖性保护作用。

结论

（）叶乙醇提取物具有作为抗氧化、抗糖尿病、抗癌和延长寿命药物的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b115/11673389/733b8d1375c3/biomedicines-12-02928-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b115/11673389/b2fc64a68dad/biomedicines-12-02928-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b115/11673389/5cc63c93b7ea/biomedicines-12-02928-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b115/11673389/cd60171a41fc/biomedicines-12-02928-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b115/11673389/cd4a0f7f06a0/biomedicines-12-02928-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b115/11673389/9a6bfc1d8e5d/biomedicines-12-02928-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b115/11673389/4ddee1bf62fe/biomedicines-12-02928-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b115/11673389/733b8d1375c3/biomedicines-12-02928-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b115/11673389/b2fc64a68dad/biomedicines-12-02928-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b115/11673389/5cc63c93b7ea/biomedicines-12-02928-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b115/11673389/cd60171a41fc/biomedicines-12-02928-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b115/11673389/cd4a0f7f06a0/biomedicines-12-02928-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b115/11673389/9a6bfc1d8e5d/biomedicines-12-02928-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b115/11673389/4ddee1bf62fe/biomedicines-12-02928-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b115/11673389/733b8d1375c3/biomedicines-12-02928-g007.jpg

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