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沙特阿拉伯的儿童哮喘:一项关于其患病率的荟萃分析见解

Childhood Asthma in Saudi Arabia: Insights from a Meta-Analysis on Its Prevalence.

作者信息

Alzayed Abdullah

机构信息

Department of Pediatrics, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317, Saudi Arabia.

出版信息

Children (Basel). 2024 Dec 20;11(12):1550. doi: 10.3390/children11121550.

Abstract

A comprehensive review and meta-analysis were conducted with the purpose of determining the extent to which asthma is prevalent among children in Saudi Arabia. This was done with the intention of addressing the dearth of data at the national level regarding this significant health concern. The study included data from PubMed, Embase, Cochrane Library, and Google Scholar for the period 2015-2024, focusing on studies that reported the prevalence of asthma among children in the country. The primary outcome was the pooled prevalence of physician-diagnosed asthma among children. Eight studies, comprising a total of 9454 children, were included in the analysis. The estimated pooled prevalence of asthma was 28.9%, with a higher prevalence observed among boys compared to girls. A random-effects model was used to account for heterogeneity among studies, which was notably high (I = 99%). Factors contributing to the high prevalence included increasing urbanization, air pollution, and specific environmental exposures, particularly in regions like Jazan. Limitations of the analysis included reliance on self-reported data without spirometric confirmation and potential publication bias. Despite these challenges, the findings emphasize the urgent need for public health interventions to reduce asthma prevalence and improve outcomes. Future research should incorporate standardized diagnostic methods and objective measurements to provide more accurate estimates and to develop effective management strategies.

摘要

为了确定沙特阿拉伯儿童哮喘的普遍程度,开展了一项全面的综述和荟萃分析。这样做是为了解决国家层面关于这一重大健康问题的数据匮乏问题。该研究纳入了2015年至2024年期间来自PubMed、Embase、Cochrane图书馆和谷歌学术的数据,重点关注报告该国儿童哮喘患病率的研究。主要结果是医生诊断的儿童哮喘合并患病率。分析纳入了八项研究,共9454名儿童。哮喘的估计合并患病率为28.9%,男孩的患病率高于女孩。采用随机效应模型来考虑研究之间的异质性,异质性显著较高(I² = 99%)。导致高患病率的因素包括城市化加剧、空气污染以及特定的环境暴露,特别是在吉赞等地区。分析的局限性包括依赖自我报告数据而无肺功能测定确认以及潜在的发表偏倚。尽管存在这些挑战,研究结果强调迫切需要采取公共卫生干预措施来降低哮喘患病率并改善治疗效果。未来的研究应采用标准化诊断方法和客观测量,以提供更准确的估计并制定有效的管理策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e4d/11727552/bf279d875b8d/children-11-01550-g001.jpg

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