This review presents a detailed examination of the most recent advancements in positron emission tomography-computed tomography (PET-CT) multimodal imaging over the past five years. The fusion of PET and CT technologies has revolutionized medical imaging, offering unprecedented insights into both anatomical structure and functional processes. The analysis delves into key technological innovations, including advancements in image reconstruction, data-driven gating, and time-of-flight capabilities, highlighting their impact on enhancing diagnostic accuracy and clinical outcomes. Illustrative case studies underscore the transformative role of PET-CT in lesion detection, disease characterization, and treatment response evaluation. Additionally, the review explores future prospects and challenges in PET-CT, advocating for the integration and evaluation of emerging technologies to improve patient care. This comprehensive synthesis aims to equip healthcare professionals, researchers, and industry stakeholders with the knowledge and tools necessary to navigate the evolving landscape of PET-CT multimodal imaging.