Kouno Nobuji, Takahashi Satoshi, Takasawa Ken, Komatsu Masaaki, Ishiguro Naoaki, Takeda Katsuji, Matsuoka Ayumu, Fujimori Maiko, Yokoyama Kazuki, Yamamoto Shun, Honma Yoshitaka, Kato Ken, Obama Kazutaka, Hamamoto Ryuji
Division of Medical AI Research and Development, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
Cancer Translational Research Team, RIKEN Center for Advanced Intelligence Project, 1-4-1 Nihonbashi, Chuo-ku, Tokyo 103-0027, Japan.
Bioengineering (Basel). 2024 Dec 5;11(12):1232. doi: 10.3390/bioengineering11121232.
Assessing objective physical function in patients with cancer is crucial for evaluating their ability to tolerate invasive treatments. Current assessment methods, such as the timed up and go (TUG) test and the short physical performance battery, tend to require additional resources and time, limiting their practicality in routine clinical practice. To address these challenges, we developed a system to assess physical function based on movements observed during clinical consultations and aimed to explore relevant features from inertial measurement unit data collected during those movements. As for the flow of the research, we first collected inertial measurement unit data from 61 patients with cancer while they replicated a series of movements in a consultation room. We then conducted correlation analyses to identify keypoints of focus and developed machine learning models to predict the TUG test outcomes using the extracted features. Regarding results, pelvic velocity variability (PVV) was identified using Lasso regression. A linear regression model using PVV as the input variable achieved a mean absolute error of 1.322 s and a correlation of 0.713 with the measured TUG results during five-fold cross-validation. Higher PVV correlated with shorter TUG test results. These findings provide a foundation for the development of an artificial intelligence-based physical function assessment system that operates without the need for additional resources.
评估癌症患者的客观身体功能对于评估他们耐受侵入性治疗的能力至关重要。当前的评估方法,如定时起立行走(TUG)测试和简短体能状况量表,往往需要额外的资源和时间,限制了它们在常规临床实践中的实用性。为应对这些挑战,我们开发了一个基于临床会诊期间观察到的动作来评估身体功能的系统,并旨在从这些动作期间收集的惯性测量单元数据中探索相关特征。至于研究流程,我们首先从61名癌症患者在会诊室重复一系列动作时收集了惯性测量单元数据。然后我们进行了相关性分析以确定重点关注的关键点,并开发了机器学习模型,使用提取的特征来预测TUG测试结果。关于结果,使用套索回归确定了骨盆速度变异性(PVV)。在五折交叉验证期间,以PVV作为输入变量的线性回归模型实现了1.322秒的平均绝对误差和与测量的TUG结果0.713的相关性。较高的PVV与较短的TUG测试结果相关。这些发现为开发无需额外资源即可运行的基于人工智能的身体功能评估系统奠定了基础。