Bartoszewska Elżbieta, Florek Kamila, Zagórski Karol, Gachowska Martyna, Wietrzyk Anna, Hutny Agata, Nowakowska-Toporowska Agnieszka, Kulbacka Julita
Faculty of Medicine, Wroclaw Medical University, L. Pasteura 1, 50-367 Wroclaw, Poland.
Student Research Group No. K148, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland.
Cells. 2024 Dec 18;13(24):2095. doi: 10.3390/cells13242095.
Understanding morphological, biochemical, and functional aspects of cell death is essential for targeting new cancer therapies. Even though many different mechanisms of cell death are identified, it is crucial to highlight the role of new and lesser-known pathways, including methuosis, alkaliptosis, and oxeiptosis. The aim of this review was to summarize the data about cell death mechanisms-methuosis, alkaliptosis, and oxeiptosis-and their role in cancer treatment. Unique molecular mechanisms and cellular outcomes characterize each of these forms of cell death. This research on methuosis, alkaliptosis, and oxeiptosis provides a better understating of cell death biology and creates novel opportunities for neoplasm management.
了解细胞死亡的形态学、生物化学和功能方面对于靶向新的癌症治疗至关重要。尽管已经确定了许多不同的细胞死亡机制，但强调新的和鲜为人知的途径的作用至关重要，包括自噬性死亡、碱中毒性细胞死亡和氧化应激性细胞死亡。这篇综述的目的是总结关于细胞死亡机制——自噬性死亡、碱中毒性细胞死亡和氧化应激性细胞死亡——及其在癌症治疗中的作用的数据。这些细胞死亡形式中的每一种都有独特的分子机制和细胞结果。对自噬性死亡、碱中毒性细胞死亡和氧化应激性细胞死亡的这项研究能更好地理解细胞死亡生物学，并为肿瘤管理创造新的机会。
