Hajibabaie Fatemeh, Abedpoor Navid, Mohamadynejad Parisa
Department of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord 88137-33395, Iran.
Department of Physiology, Medicinal Plants Research Center, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan 81551-39998, Iran.
Biology (Basel). 2023 Nov 13;12(11):1426. doi: 10.3390/biology12111426.
The former conventional belief was that cell death resulted from either apoptosis or necrosis; however, in recent years, different pathways through which a cell can undergo cell death have been discovered. Various types of cell death are distinguished by specific morphological alterations in the cell's structure, coupled with numerous biological activation processes. Various diseases, such as cancers, can occur due to the accumulation of damaged cells in the body caused by the dysregulation and failure of cell death. Thus, comprehending these cell death pathways is crucial for formulating effective therapeutic strategies. We focused on providing a comprehensive overview of the existing literature pertaining to various forms of cell death, encompassing apoptosis, anoikis, pyroptosis, NETosis, ferroptosis, autophagy, entosis, methuosis, paraptosis, mitoptosis, parthanatos, necroptosis, and necrosis.
以前的传统观念认为，细胞死亡要么是由凋亡引起，要么是由坏死引起；然而，近年来，已经发现了细胞可能经历细胞死亡的不同途径。各种类型的细胞死亡通过细胞结构中特定的形态学改变以及众多生物激活过程来区分。各种疾病，如癌症，可能由于细胞死亡失调和失败导致体内受损细胞积累而发生。因此，理解这些细胞死亡途径对于制定有效的治疗策略至关重要。我们专注于全面概述与各种形式的细胞死亡相关的现有文献，包括凋亡、失巢凋亡、焦亡、中性粒细胞胞外陷阱形成、铁死亡、自噬、内吞作用、溶酶体储存障碍性细胞死亡、副凋亡、线粒体凋亡、PARP-1依赖性细胞死亡、坏死性凋亡和坏死。
