Vida Balázs, Lintner Balázs, Várbíró Szabolcs, Merkely Petra, Lőczi Lotti Lúcia, Ács Nándor, Tóth Richárd, Keszthelyi Márton
Department of Obstetrics and Gynecology, Semmelweis University, 1082 Budapest, Hungary.
Workgroup of Research Management, Doctoral School, Semmelweis University, 1085 Budapest, Hungary.
Life (Basel). 2024 Nov 23;14(12):1538. doi: 10.3390/life14121538.
This systematic review and meta-analysis protocol aims to evaluate the comparative efficacy of different sentinel lymph node (SLN) detection techniques in the management of vulvar cancer. Vulvar cancer, though rare, predominantly affects older women and requires effective management strategies. The SLN technique has become a standard approach for early-stage cases, offering reduced morbidity compared to complete lymphadenectomy. Currently, various SLN detection methods exist, including the use of Technetium-99m (Tc99m), Indocyanine Green (ICG), and superparamagnetic iron oxide (SPIO), but there is a lack of comprehensive comparison of their efficacy. This review will systematically search relevant databases, including PubMed, Scopus, Cochrane, Web of Science and Embase following PRISMA guidelines, to gather data from clinical trials. The primary outcome will be the detection rates of SLN techniques with secondary outcomes examining patient characteristics and procedural factors. The analysis will utilize random-effects models to compare detection rates across studies. The results of this study aim to provide insights into the optimal SLN detection method with potential implications for clinical practice guidelines in vulvar cancer management. The protocol is registered under the PROSPERO registration number CRD42024590774.
本系统评价和荟萃分析方案旨在评估不同前哨淋巴结（SLN）检测技术在外阴癌治疗中的比较疗效。外阴癌虽然罕见，但主要影响老年女性，需要有效的管理策略。SLN技术已成为早期病例的标准方法，与根治性淋巴结清扫术相比，其发病率更低。目前，存在多种SLN检测方法，包括使用锝-99m（Tc99m）、吲哚菁绿（ICG）和超顺磁性氧化铁（SPIO），但缺乏对它们疗效的全面比较。本综述将按照PRISMA指南系统检索相关数据库，包括PubMed、Scopus、Cochrane、Web of Science和Embase，以收集来自临床试验的数据。主要结局将是SLN技术的检测率，次要结局将检查患者特征和手术因素。分析将采用随机效应模型比较各研究的检测率。本研究结果旨在深入了解最佳的SLN检测方法，对外阴癌管理的临床实践指南可能产生影响。该方案已在PROSPERO注册号CRD42024590774下注册。
