Schulz Franziska, Foldenauer Ann Christina, Weidmann Lara, Thomann Anne Kerstin, Tal Andrea Oliver, Plachta-Danielzik Sandra, Krause Thomas, Bokemeyer Bernd, Zeuzem Stefan, Kubesch Alica, Blumenstein Irina
Goethe University Frankfurt, Frankfurt University Hospital, Medical Clinic 1, 60596 Frankfurt am Main, Germany.
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 60596 Frankfurt am Main, Germany.
J Clin Med. 2024 Dec 20;13(24):7806. doi: 10.3390/jcm13247806.
Inflammatory bowel disease (IBD) remains an incurable illness. Patients with IBD show gender-specific differences in various aspects of the disease. There is still uncertainty about the causality of the differences. The aim of this study was to determine the most relevant psychophysiological gender-specific differences in IBD. For this purpose, a questionnaire survey was conducted on disease activity and psychological concomitant diseases in patients with IBD (n = 300). Among the 218 patients with IBD who provided gender information, both genders were equally distributed. Females with IBD are significantly more affected by IBD-related symptoms than men. Disease activity Scores Harvey-Bradshaw Index (HBI), Partial Mayo Score (pMAYO) showed no significant differences between the sexes in the subgroups with CD (HBI, m: 3 (IQR 1-6), w: 4 (IQR 2-8), = 0.0677) and UC (pMAYO, m: 1 (IQR 0-4), w: 3 (IQR 0-5), = 0.2118). IBD Questionnaire (IBDQ)shows significant differences in the gender-specific analysis. The mean value of the IBDQ total score of the female participants was 4.4 (SD 1.1) and that of men was 5.0 (SD 1.0) ( = 0.0002). There is a great need to investigate the causality of gender-specific differences in greater depth.
炎症性肠病（IBD）仍然是一种无法治愈的疾病。IBD患者在疾病的各个方面表现出性别特异性差异。这些差异的因果关系仍不确定。本研究的目的是确定IBD中最相关的心理生理性别特异性差异。为此，对IBD患者（n = 300）的疾病活动和心理伴随疾病进行了问卷调查。在提供性别信息的218例IBD患者中，男女分布均衡。患有IBD的女性比男性受IBD相关症状的影响更大。疾病活动评分哈维-布拉德肖指数（HBI）、部分梅奥评分（pMAYO）在克罗恩病（CD）亚组（HBI，男性：3（四分位间距1-6），女性：4（四分位间距2-8），P = 0.0677）和溃疡性结肠炎（UC）亚组（pMAYO，男性：1（四分位间距0-4），女性：3（四分位间距0-5），P = 0.2118）中，性别之间无显著差异。IBD问卷（IBDQ）在性别特异性分析中显示出显著差异。女性参与者的IBDQ总分平均值为4.4（标准差1.1），男性为5.0（标准差1.0）（P = 0.0002）。非常有必要更深入地研究性别特异性差异的因果关系。
