Beça Sara, Baños Núria, Borrell Maria, Ruiz-Ortiz Estíbaliz, Pérez-Isidro Albert, Cervera Ricard, Reverter Joan Carles, Tàssies Dolores, Espinosa Gerard
Department of Autoimmune Diseases, Reference Centre for Systemic Autoimmune Diseases (UEC/CSUR) of the Catalan and Spanish Health Systems-Member of ERNReCONNET, Hospital Clínic, University of Barcelona, 08036 Barcelona, Catalonia, Spain.
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Catalonia, Spain.
J Clin Med. 2024 Dec 23;13(24):7862. doi: 10.3390/jcm13247862.
: The clinical and laboratory features of patients with non-criteria obstetric antiphospholipid syndrome (NC-OAPS), as well as their pregnancy outcomes and ideal treatment are not clearly determined. The aim of this study is to describe the characteristics and outcomes of pregnancies in NC-OAPS and compare them with an obstetric APS (OAPS) cohort. : This is a retrospective study conducted on a cohort of women referred to a high-risk obstetric unit of a tertiary hospital. Women that were classified as having OAPS or NC-OAPS were included and compared in terms of clinical and laboratory characteristics, management, and subsequent pregnancy outcomes. : We identified 107 women with 143 pregnancies, 91 with NC-OAPS and 16 with OAPS. There were no differences in demographic features between both groups. Women with NC-OAPS were more likely to have recurrent implantation failure and were predominantly positive for a single antiphospholipid antibody (aPL) subtype. Both groups were treated similarly (low dose aspirin plus low molecular weight heparin in 87.4% of NC-OAPS and 83.3% of OAPS, > 0.05). Live birth rate (82.4% and 75.0%, respectively, > 0.05) and adverse pregnancy outcomes (31.6% vs. 37.5%, > 0.05) in subsequent pregnancies during follow-up were also similar between groups. : This study revealed differences in the previous pregnancy morbidity and aPL profiles in women with NC-OAPS and OAPS, although the therapeutic approach and the outcomes of subsequent pregnancies were similar in both groups.
非标准型产科抗磷脂综合征（NC - OAPS）患者的临床和实验室特征、妊娠结局及理想治疗方法尚未明确确定。本研究旨在描述NC - OAPS患者妊娠的特征和结局，并与产科抗磷脂综合征（OAPS）队列进行比较。
这是一项对转诊至三级医院高危产科病房的女性队列进行的回顾性研究。纳入被分类为患有OAPS或NC - OAPS的女性，并在临床和实验室特征、管理及后续妊娠结局方面进行比较。
我们确定了107名女性的143次妊娠，其中91名患有NC - OAPS，16名患有OAPS。两组在人口统计学特征上无差异。NC - OAPS女性更易发生反复种植失败，且主要为单一抗磷脂抗体（aPL）亚型阳性。两组治疗方式相似（87.4%的NC - OAPS患者和83.3%的OAPS患者接受低剂量阿司匹林加低分子量肝素治疗，P＞0.05）。随访期间后续妊娠的活产率（分别为82.4%和75.0%，P＞0.05）及不良妊娠结局（分别为31.6%和37.5%，P＞0.05）在两组间也相似。
本研究揭示了NC - OAPS和OAPS女性既往妊娠发病率及aPL谱的差异，尽管两组的治疗方法及后续妊娠结局相似。
