Ganotopoulou Asimina, Korakas Emmanouil, Pliouta Loukia, Kountouri Aikaterini, Pililis Sotirios, Lampsas Stamatios, Ikonomidis Ignatios, Rallidis Loukianos S, Papazafiropoulou Athanasia, Melidonis Andreas, Lambadiari Vaia
Research Unit and Diabetes Centre, 2nd Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece.
Department of Internal Medicine and Diabetes Centre, Tzaneio General Hospital of Piraeus, 185 36 Piraeus, Greece.
Medicina (Kaunas). 2024 Dec 2;60(12):1981. doi: 10.3390/medicina60121981.
A disintegrin and metalloproteinase with thrombospondin motifs-7 (ADAMTS-7) belongs to the family of metalloproteinases that contributes to tissue homeostasis during morphogenesis and reproduction. These metalloproteinases regulate various cell functions such as cell proliferation, are important regulators in tissue regeneration, and play a role in vascular remodelling, which is involved in atherosclerosis development. Despite the well-established association between ADAMTS-7 and atherosclerotic disease, data regarding the metalloproteinase's association with LV function remain scarce. The aim of this study was to investigate the association of ADAMTS-7 levels with diastolic dysfunction and various echocardiographic parameters in patients with type 2 diabetes mellitus. All patients underwent a clinical, vascular, and echocardiographic examination during their visit. Plasma ADAMTS-7 levels were measured in all patients. The results showed that diastolic dysfunction was strongly associated with age, but had no statistically significant association with ADAMTS-7. When individual echocardiographic parameters were examined, ADAMTS-7 levels showed a positive tendency only with deceleration time (DT), with the other echocardiographic parameters being positively associated only with age. The possible role of ADAMTS-7 in diastolic dysfunction and in the development and progression of heart failure in patients with type 2 diabetes mellitus deserves further investigation.
含血小板反应蛋白基序的解聚素和金属蛋白酶-7（ADAMTS-7）属于金属蛋白酶家族，在形态发生和生殖过程中有助于维持组织稳态。这些金属蛋白酶调节多种细胞功能，如细胞增殖，是组织再生的重要调节因子，并在血管重塑中发挥作用，而血管重塑与动脉粥样硬化的发展有关。尽管ADAMTS-7与动脉粥样硬化疾病之间的关联已得到充分证实，但关于该金属蛋白酶与左心室功能关联的数据仍然稀少。本研究的目的是调查2型糖尿病患者中ADAMTS-7水平与舒张功能障碍及各种超声心动图参数之间的关联。所有患者在就诊期间均接受了临床、血管和超声心动图检查。测量了所有患者的血浆ADAMTS-7水平。结果显示，舒张功能障碍与年龄密切相关，但与ADAMTS-7无统计学显著关联。在检查各个超声心动图参数时，ADAMTS-7水平仅与减速时间（DT）呈正相关趋势，其他超声心动图参数仅与年龄呈正相关。ADAMTS-7在2型糖尿病患者舒张功能障碍以及心力衰竭发生和发展中的可能作用值得进一步研究。
