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急性肾损伤中毒患者的毒理学护理与非毒理学护理的比较分析

A Comparative Analysis of Toxicology and Non-Toxicology Care in Intoxicated Patients with Acute Kidney Injury.

作者信息

Pan Chi-Syuan, Chen Chun-Hung, Chen Wei-Kung, Mu Han-Wei, Yang Kai-Wei, Yu Jiun-Hao

机构信息

Department of Emergency Medicine, China Medical University Hospital, Taichung 404, Taiwan.

Department of Emergency Medicine, China Medical University Hsinchu Hospital, China Medical University, Hsinchu 302, Taiwan.

出版信息

Medicina (Kaunas). 2024 Dec 3;60(12):1997. doi: 10.3390/medicina60121997.

DOI:10.3390/medicina60121997
PMID:39768877
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11728168/
Abstract

: Intoxicated patients with acute kidney injury (AKI) experience high morbidity and mortality. While prior studies suggest that toxicology care settings improve outcomes, the impact of care settings on patients with AKI remains unclear. This study aimed to compare the outcomes of intoxicated patients with AKI managed in toxicology versus non-toxicology care settings. : This retrospective cohort study included intoxicated patients admitted to a tertiary hospital between January 2022 and December 2023. Patients were categorized into toxicology and non-toxicology care settings. Demographic characteristics, clinical outcomes focusing on mortality and length of hospital stay, and evaluation scores were compared. : A total of 31 intoxicated patients with AKI were included in the study. There were no significant differences in mortality or hospital length of stay between toxicology and non-toxicology care settings. However, the mortality rate in the AKI group was significantly higher (16%) compared to intoxicated patients without AKI (1.9%). Additionally, hospital stays were consistently longer in the AKI group than in the non-AKI group across all age groups. : Hospital length of stay and mortality did not differ significantly between toxicology and non-toxicology care settings for intoxicated patients with AKI. However, both hospital length of stay and mortality were notably higher in patients with AKI compared to those without AKI.

摘要

急性肾损伤(AKI)的中毒患者具有较高的发病率和死亡率。虽然先前的研究表明,毒理学护理环境可改善预后,但护理环境对AKI患者的影响仍不明确。本研究旨在比较在毒理学护理环境与非毒理学护理环境中接受治疗的AKI中毒患者的预后。

这项回顾性队列研究纳入了2022年1月至2023年12月期间入住一家三级医院的中毒患者。患者被分为毒理学护理组和非毒理学护理组。比较了人口统计学特征、以死亡率和住院时间为重点的临床结局以及评估分数。

本研究共纳入31例AKI中毒患者。毒理学护理组和非毒理学护理组在死亡率或住院时间方面没有显著差异。然而,AKI组的死亡率(16%)显著高于无AKI的中毒患者(1.9%)。此外,在所有年龄组中,AKI组的住院时间始终比非AKI组更长。

对于AKI中毒患者,毒理学护理组和非毒理学护理组在住院时间和死亡率方面没有显著差异。然而,与无AKI的患者相比,AKI患者的住院时间和死亡率均显著更高。

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本文引用的文献

1
Poisoning-Induced Acute Kidney Injury: A Review.中毒性急性肾损伤:综述。
Medicina (Kaunas). 2024 Aug 12;60(8):1302. doi: 10.3390/medicina60081302.
2
Comparison of the new-Poisoning Mortality Score and the Modified Early Warning Score for predicting in-hospital mortality in patients with acute poisoning.新中毒病死率评分与改良早期预警评分预测急性中毒患者院内病死率的比较。
Clin Toxicol (Phila). 2024 Jan;62(1):1-9. doi: 10.1080/15563650.2024.2310743. Epub 2024 Feb 29.
3
Evaluation of the new poisoning mortality score in comparison with PSS and SOFA scoring systems to predict mortality in poisoned patients admitted to the intensive care unit.
将新的中毒死亡率评分与PSS和SOFA评分系统相比较,以预测入住重症监护病房的中毒患者的死亡率。
Toxicol Res (Camb). 2023 Dec 5;13(1):tfad113. doi: 10.1093/toxres/tfad113. eCollection 2024 Feb.
4
Evaluation of the association of length of stay in hospital and outcomes.评价住院时间与结局的相关性。
Int J Qual Health Care. 2022 May 2;34(2). doi: 10.1093/intqhc/mzab160.
5
Relationship between acute kidney injury and mortality in poisoning - a systematic review and metanalysis.中毒患者急性肾损伤与死亡率的关系:系统评价和荟萃分析。
Clin Toxicol (Phila). 2021 Sep;59(9):771-779. doi: 10.1080/15563650.2021.1928161. Epub 2021 Jun 3.
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Emergency mortality of non-trauma patients was predicted by qSOFA score.qSOFA 评分可预测非创伤患者的急诊死亡率。
PLoS One. 2021 Feb 24;16(2):e0247577. doi: 10.1371/journal.pone.0247577. eCollection 2021.
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Development and validation of new poisoning mortality score system for patients with acute poisoning at the emergency department.建立与验证新的急诊急性中毒患者中毒死亡率评分系统。
Crit Care. 2021 Jan 18;25(1):29. doi: 10.1186/s13054-020-03408-1.
8
Incidence of intoxication events and patient outcomes in Taiwan: A nationwide population-based observational study.台湾地区中毒事件发生率及患者结局:一项基于全国人口的观察性研究。
PLoS One. 2020 Dec 23;15(12):e0244438. doi: 10.1371/journal.pone.0244438. eCollection 2020.
9
Acute toxic kidney injury.急性毒性肾损伤。
Ren Fail. 2019 Nov;41(1):576-594. doi: 10.1080/0886022X.2019.1628780.
10
The impact of the introduction of a toxicology service on the intensive care unit.毒物学服务引入对重症监护病房的影响。
Clin Toxicol (Phila). 2019 Sep;57(9):778-783. doi: 10.1080/15563650.2019.1566553. Epub 2019 Feb 7.