Epelde Francisco
Medicine Department, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, 08208 Sabadell, Spain.
Medicina (Kaunas). 2024 Dec 6;60(12):2017. doi: 10.3390/medicina60122017.
Heart failure with reduced ejection fraction (HFrEF) is a condition marked by diminished cardiac output and impaired oxygen delivery to tissues. Exercise, once avoided in HFrEF patients due to safety concerns, is now recognized as an important therapeutic intervention. Structured exercise improves various physiological, biochemical, and analytical parameters, including cardiac output, endothelial function, skeletal muscle performance, and autonomic regulation. Biochemically, exercise induces favorable changes in inflammatory markers, lipid profiles, glucose metabolism, and renal function. This paper reviews these changes, highlighting how exercise can be safely incorporated into HFrEF management. Further research is needed to tailor exercise interventions for individual patients to optimize outcomes.
射血分数降低的心力衰竭（HFrEF）是一种以心输出量减少和组织氧输送受损为特征的病症。由于安全担忧，运动曾一度被HFrEF患者所避免，而现在它被认为是一种重要的治疗干预措施。结构化运动可改善各种生理、生化和分析参数，包括心输出量、内皮功能、骨骼肌性能和自主调节。在生化方面，运动可诱导炎症标志物、血脂谱、葡萄糖代谢和肾功能发生有益变化。本文综述了这些变化，强调了如何将运动安全地纳入HFrEF的管理中。需要进一步研究为个体患者量身定制运动干预措施，以优化治疗效果。
