Sadek Zahra, Ramadan Wiam, Ahmaidi Said, Youness Mahmoud, Joumaa Wissam H
Laboratory EA-3300 (APERE), Adaptations Physiologiques à l'Exercice et Réadaptation à l'Effort, Picardie Jules Verne University.
Rammal Hassan Rammal Laboratory, PhyToxE Physio-toxicité environnemental, Faculty of Sciences, Lebanese University.
Int Heart J. 2024;65(1):71-83. doi: 10.1536/ihj.23-326.
Exercise intolerance and dyspnea are the major symptoms of patients with chronic heart failure (CHF) and are associated with a poor quality of life. In addition to impaired central hemodynamics, symptoms may be attributed to changes in peripheral skeletal muscles. This study aimed to evaluate the effects of aerobic interval training (AIT) combined with inspiratory muscle training (IMT) on cardiac and skeletal muscle function and on functional capacity and dyspnea in patients with CHF and inspiratory muscle weakness.Left ventricle ejection fraction was improved significantly after AIT and AIT & IMT with a high percentage of amelioration (17%, P < 0.042) in the combined group compared to the control group. Therefore, we showed a significant improvement in maximal voluntary isometric force, isometric endurance time, root mean square, and frequency median in both strength and endurance manipulations in the aerobic and combined group; however, the improvement was superior in the combined group compared to the control group. Significant amelioration was proved in functional capacity and dyspnea after all types of training but was performed at 18% higher in 6 minutes' walk test and 43% lower in dyspnea for the combined group compared to the control group.Combining AIT to IMT had optimized exercise training benefits in reversing the cardiac remodeling process and improving skeletal muscle function, functional capacity, and dyspnea in patients with CHF.
运动不耐受和呼吸困难是慢性心力衰竭（CHF）患者的主要症状，且与生活质量差相关。除了中心血流动力学受损外，症状可能还归因于外周骨骼肌的变化。本研究旨在评估有氧间歇训练（AIT）联合吸气肌训练（IMT）对CHF合并吸气肌无力患者心脏和骨骼肌功能、功能能力及呼吸困难的影响。与对照组相比，联合组在进行AIT以及AIT与IMT联合训练后左心室射血分数显著改善，改善率较高（17%，P<0.042）。因此，我们发现有氧组和联合组在力量和耐力训练中，最大自主等长肌力、等长耐力时间、均方根和频率中位数均有显著改善；然而，联合组的改善优于对照组。所有类型的训练后功能能力和呼吸困难均有显著改善，但与对照组相比，联合组在6分钟步行试验中提高了18%，在呼吸困难方面降低了43%。将AIT与IMT相结合可优化运动训练效果，逆转CHF患者的心脏重塑过程，改善骨骼肌功能、功能能力及呼吸困难。
