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铁死亡在胰腺癌发生发展及治疗中的新情况

The Emerging Scenario of Ferroptosis in Pancreatic Cancer Tumorigenesis and Treatment.

作者信息

Lyu Hao, Kong Jinghua, Chen Jiasi, Zhang Rui, Xiao Shuai, Guo Dong, Zhang Qi, Chen Xing-Zhen, Tang Jingfeng, Zhou Cefan

机构信息

National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, China.

Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan 430068, China.

出版信息

Int J Mol Sci. 2024 Dec 12;25(24):13334. doi: 10.3390/ijms252413334.

DOI:10.3390/ijms252413334
PMID:39769097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11727763/
Abstract

Pancreatic cancer remains one of the most lethal forms of cancer. Currently, there is a lack of effective drug treatments for pancreatic cancer. However, as a newly discovered form of non-apoptotic cell death, ferroptosis has garnered increasing attention in relation to pancreatic cancer. Understanding the role of ferroptosis in the tumorigenesis and treatment of pancreatic cancer may enable more effective clinical trials and treatments for pancreatic cancer and may minimize side effects or restrict the emergence of drug resistance. In this review, we summarize the current knowledge regarding the process and underlying mechanisms of ferroptosis, as well as its dual role in both promoting tumorigenesis and facilitating treatment strategies for pancreatic cancer. Additionally, how ferroptosis is implicated in the development of pancreatitis and insulin resistance, indicating that ferroptosis may play an important role in the risk of pancreatitis- and insulin-resistance-related pancreatic cancers, is also addressed.

摘要

胰腺癌仍然是最致命的癌症形式之一。目前，缺乏针对胰腺癌的有效药物治疗方法。然而，作为一种新发现的非凋亡性细胞死亡形式，铁死亡在胰腺癌方面受到了越来越多的关注。了解铁死亡在胰腺癌发生和治疗中的作用，可能有助于开展更有效的胰腺癌临床试验和治疗，并可能将副作用降至最低或限制耐药性的出现。在这篇综述中，我们总结了关于铁死亡过程和潜在机制的当前知识，以及其在促进胰腺癌发生和推动胰腺癌治疗策略方面的双重作用。此外，还讨论了铁死亡如何与胰腺炎和胰岛素抵抗的发展相关联，这表明铁死亡可能在与胰腺炎和胰岛素抵抗相关的胰腺癌风险中发挥重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9057/11727763/6b26ce02ac80/ijms-25-13334-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9057/11727763/7a5e0d302be9/ijms-25-13334-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9057/11727763/69a45c3ddc20/ijms-25-13334-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9057/11727763/a5cda62a9d9c/ijms-25-13334-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9057/11727763/5fecdd6bbb57/ijms-25-13334-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9057/11727763/a597dbdd0457/ijms-25-13334-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9057/11727763/6b26ce02ac80/ijms-25-13334-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9057/11727763/7a5e0d302be9/ijms-25-13334-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9057/11727763/69a45c3ddc20/ijms-25-13334-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9057/11727763/a5cda62a9d9c/ijms-25-13334-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9057/11727763/5fecdd6bbb57/ijms-25-13334-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9057/11727763/a597dbdd0457/ijms-25-13334-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9057/11727763/6b26ce02ac80/ijms-25-13334-g006.jpg

相似文献

[1]
The Emerging Scenario of Ferroptosis in Pancreatic Cancer Tumorigenesis and Treatment.

Int J Mol Sci. 2024-12-12

[2]
MGST1 facilitates novel KRAS inhibitor resistance in KRAS-mutated pancreatic ductal adenocarcinoma by inhibiting ferroptosis.

Mol Med. 2024-11-5

[3]
Targeting ferroptosis in pancreatic cancer: a double-edged sword.

Trends Cancer. 2021-10

[4]
Ferroptosis: At the Crossroad of Gemcitabine Resistance and Tumorigenesis in Pancreatic Cancer.

Int J Mol Sci. 2021-10-10

[5]
Emerging Potential Mechanism and Therapeutic Target of Ferroptosis in PDAC: A Promising Future.

Int J Mol Sci. 2022-11-30

[6]
ARID3A enhances chemoresistance of pancreatic cancer via inhibiting PTEN-induced ferroptosis.

Redox Biol. 2024-7

[7]
DHA exhibits synergistic therapeutic efficacy with cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via modulation of iron metabolism.

Cell Death Dis. 2021-7-15

[8]
Ferroptosis in pancreatic diseases: potential opportunities and challenges that require attention.

Hum Cell. 2023-7

[9]
Ferroptosis: A New Promising Target for Lung Cancer Therapy.

Oxid Med Cell Longev. 2021

[10]
TRIM21-mediated METTL3 degradation promotes PDAC ferroptosis and enhances the efficacy of Anti-PD-1 immunotherapy.

Cell Death Dis. 2025-4-3

本文引用的文献

[1]
Role and mechanism of myonectin in severe acute pancreatitis: a crosstalk between skeletal muscle and pancreas.

Skelet Muscle. 2024-12-3

[2]
Oncogenic KRAS Promotes Ferroptosis in Pancreatic Cancer Through Regulation of the Fosl1-Tfrc Axis.

Pancreas. 2025-3-1

[3]
Mechanisms and cross-talk of regulated cell death and their epigenetic modifications in tumor progression.

Mol Cancer. 2024-11-29

[4]
Ferroptosis in Cancer: Epigenetic Control and Therapeutic Opportunities.

Biomolecules. 2024-11-13

[5]
ELAVL1-dependent SOAT2 exacerbated the pancreatitis-like cellular injury of AR42J cells induced by hyperstimulation with caerulein.

Kaohsiung J Med Sci. 2025-1

[6]
OSGIN1 promotes ferroptosis resistance by directly enhancing GCLM activity.

Biochem Biophys Res Commun. 2024-12-25

[7]
Ferroptosis: mechanisms and therapeutic targets.

MedComm (2020). 2024-11-20

[8]
TMOD3 accelerated resistance to immunotherapy in KRAS-mutated pancreatic cancer through promoting autophagy-dependent degradation of ASCL4.

Drug Resist Updat. 2025-1

[9]
Immortalized mesenchymal stromal cells overexpressing alpha-1 antitrypsin protect acinar cells from apoptotic and ferroptotic cell death.

J Cell Mol Med. 2024-10

[10]
IL15RA-STAT3-GPX4/ACSL3 signaling leads to ferroptosis resistance in pancreatic cancer.

Acta Biochim Biophys Sin (Shanghai). 2024-10-12

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