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从超临界二氧化碳提取物中分离出的生物活性化合物的抗真菌特性

Antifungal Properties of Bioactive Compounds Isolated from Supercritical Carbon Dioxide Extract.

作者信息

Tyśkiewicz Katarzyna, Rüttler Felix, Tyśkiewicz Renata, Nowak Artur, Gruba Marcin, Wziątek Anita, Dębczak Agnieszka, Sandomierski Michał, Vetter Walter

机构信息

Department of Food Chemistry (170B), Institute of Food Chemistry, University of Hohenheim, Garbenstraβe 28, D-70599 Stuttgart, Germany.

Analytical Laboratory, Łukasiewicz Research Network-New Chemical Syntheses Institute, Al. Tysiąclecia Państwa Polskiego 13A, 24-110 Puławy, Poland.

出版信息

Molecules. 2024 Dec 17;29(24):5957. doi: 10.3390/molecules29245957.

DOI:10.3390/molecules29245957
PMID:39770045
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11677683/
Abstract

The exploration of natural antifungal substances from algal origins is significant due to the increasing resistance of pathogens to conventional antifungal agents and the growing consumer demand for natural products. This manuscript represents the inaugural investigation into the antifungal attributes of bioactive compounds extracted from via supercritical carbon dioxide (scCO) extraction utilizing contemporary countercurrent chromatography (CCC). In aligning with the prospective utilization of this extract within the agricultural sector, this study also serves as the preliminary report demonstrating the capability of scCO extract to enhance the activity of plant resistance enzymes. The fractions obtained through CCC were subjected to evaluation for their efficacy in inhibiting the macrospores of . The CCC methodology facilitated the successful separation of fatty acids (reaching up to 82.0 wt.% in a given fraction) and fucosterol (attaining up to 79.4 wt.% in another fraction). All CCC fractions at the concentration of 1.0% were found to inhibit 100% of growth. Moreover, scCO extract was able to activate plant resistance enzymes (Catalase, Ascorbic Peroxidase, Guaiacol Peroxidase, Phenylalanine Ammonia-Lyase, and Phenylalanine Ammonia-Lyase Activity).

摘要

由于病原体对传统抗真菌剂的耐药性不断增加以及消费者对天然产品的需求不断增长，探索源自藻类的天然抗真菌物质具有重要意义。本手稿代表了对通过超临界二氧化碳（scCO₂）萃取并利用当代逆流色谱法（CCC）从[具体藻类]中提取的生物活性化合物的抗真菌特性进行的首次研究。为了与该提取物在农业领域的潜在用途相一致，本研究还作为初步报告，证明了scCO₂提取物增强植物抗性酶活性的能力。通过CCC获得的馏分对其抑制[某种真菌]大孢子的功效进行了评估。CCC方法成功分离出了脂肪酸（在某一馏分中含量高达82.0 wt.%）和岩藻甾醇（在另一馏分中含量高达79.4 wt.%）。发现所有浓度为1.0%的CCC馏分均可100%抑制[某种真菌]的生长。此外，scCO₂提取物能够激活植物抗性酶（过氧化氢酶、抗坏血酸过氧化物酶、愈创木酚过氧化物酶、苯丙氨酸解氨酶和苯丙氨酸解氨酶活性）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ad1/11677683/efde79a23027/molecules-29-05957-g011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ad1/11677683/3e973be9246b/molecules-29-05957-g005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ad1/11677683/1fa514840f88/molecules-29-05957-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ad1/11677683/0b4a251b21f7/molecules-29-05957-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ad1/11677683/efde79a23027/molecules-29-05957-g011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ad1/11677683/3e973be9246b/molecules-29-05957-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ad1/11677683/00e756106606/molecules-29-05957-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ad1/11677683/ab71ac959dcd/molecules-29-05957-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ad1/11677683/f4af11d8d6a7/molecules-29-05957-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ad1/11677683/1fa514840f88/molecules-29-05957-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ad1/11677683/efde79a23027/molecules-29-05957-g011.jpg

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