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用于癌症同步成像与治疗的纳米诊疗系统进展：过去五年综述

Advances in Nanotheranostic Systems for Concurrent Cancer Imaging and Therapy: An Overview of the Last 5 Years.

作者信息

Lankoff Anna Małgorzata, Czerwińska Malwina, Kruszewski Marcin

机构信息

Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland.

Department of Medical Biology, Institute of Biology, Jan Kochanowski University, Uniwersytecka 15, 25-406 Kielce, Poland.

出版信息

Molecules. 2024 Dec 19;29(24):5985. doi: 10.3390/molecules29245985.

DOI:10.3390/molecules29245985
PMID:39770074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11677634/
Abstract

The rapid development of nanotechnology during the last two decades has created new opportunities to design and generate more advanced nanotheranostics with diversified capabilities for diagnosis, drug delivery, and treatment response monitoring in a single platform. To date, several approaches have been employed in order to develop nanotheranostics. The purpose of this review is to briefly discuss the key components of nanotheranostic systems, to present the conventional and upcoming imaging and therapeutic modalities that employ nanotheranostic systems, and to evaluate recent progress in the field of cancer nanotheranostic systems in the past five years (2020-2024). Special attention is focused on the design of cancer nanotheranostic systems, their composition, specificity, potential for multimodal imaging and therapy, and in vitro and in vivo characterization.

摘要

在过去二十年中，纳米技术的迅速发展为设计和生成更先进的纳米诊疗系统创造了新机遇，这些系统在单一平台上具备用于诊断、药物递送和治疗反应监测的多样化能力。迄今为止，已采用多种方法来开发纳米诊疗系统。本综述的目的是简要讨论纳米诊疗系统的关键组成部分，介绍采用纳米诊疗系统的传统和新兴成像及治疗方式，并评估过去五年（2020 - 2024年）癌症纳米诊疗系统领域的最新进展。特别关注癌症纳米诊疗系统的设计、其组成、特异性、多模态成像和治疗潜力以及体外和体内表征。

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