Krisanits Bradley A, Kaur Bhoomika, Fahey Jed W, Turner David P
Department of Surgery, School of Medicine, Virginia Commonwealth University, Richmond, VA 23284, USA.
Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23284, USA.
Molecules. 2024 Dec 19;29(24):5986. doi: 10.3390/molecules29245986.
Isothiocyanates (ITCs), found in edible plants such as cruciferous vegetables, are a group of reactive organo-sulfur phytochemicals produced by the hydrolysis of precursors known as glucosinolates. ITCs have been studied extensively both in vivo and in vitro to define their therapeutic potential for the treatment of chronic health conditions. Therapeutically, they have shown an intrinsic ability to inhibit oxidative and inflammatory phenotypes to support enhanced health. This review summarizes the current evidence supporting the observation that the antioxidant and anti-inflammatory activities of ITCs temper the pathogenic effects of a group of reactive metabolites called advanced glycation end products (AGEs). AGE exposure has significantly increased across the lifespan due to health risk factors that include dietary intake, a sedentary lifestyle, and comorbid conditions. By contributing to a chronic cycle of inflammatory stress through the aberrant activation of the transmembrane receptor for AGE (RAGE), increased AGE bioavailability is associated with chronic disease onset, progression, and severity. This review debates the potential molecular mechanisms by which ITCs may inhibit AGE bioavailability to reduce RAGE-mediated pro-oxidant and pro-inflammatory phenotypes. Bringing to light the molecular impact that ITCs may have on AGE biogenesis may stimulate novel intervention strategies for reversing or preventing the impact of lifestyle factors on chronic disease risk.
异硫氰酸盐（ITCs）存在于十字花科蔬菜等可食用植物中，是一类由硫代葡萄糖苷前体水解产生的活性有机硫植物化学物质。ITCs已在体内和体外进行了广泛研究，以确定其在治疗慢性健康状况方面的治疗潜力。在治疗方面，它们显示出抑制氧化和炎症表型以促进健康的内在能力。本综述总结了目前支持以下观察结果的证据：ITCs的抗氧化和抗炎活性可缓解一类称为晚期糖基化终产物（AGEs）的活性代谢物的致病作用。由于包括饮食摄入、久坐不动的生活方式和合并症在内的健康风险因素，一生中AGE暴露显著增加。通过异常激活AGE跨膜受体（RAGE）导致炎症应激的慢性循环，AGE生物利用度增加与慢性疾病的发生、发展和严重程度相关。本综述探讨了ITCs可能抑制AGE生物利用度以减少RAGE介导的促氧化和促炎表型的潜在分子机制。揭示ITCs可能对AGE生物合成产生的分子影响，可能会激发新的干预策略，以逆转或预防生活方式因素对慢性病风险的影响。
