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ATP结合盒转运体与溶质载体转运体：通过结构和建模方法理解其机制及药物调控

ATP-Binding Cassette and Solute Carrier Transporters: Understanding Their Mechanisms and Drug Modulation Through Structural and Modeling Approaches.

作者信息

Elbahnsi Ahmad, Dudas Balint, Callebaut Isabelle, Hinzpeter Alexandre, Miteva Maria A

机构信息

Inserm U1268 MCTR, CiTCoM UMR 8038 CNRS, Université Paris Cité, 75006 Paris, France.

Muséum National d'Histoire Naturelle, UMR CNRS 7590, Institut de Minéralogie, de Physique des Matériaux et de Cosmochimie-IMPMC, Sorbonne Université, 75005 Paris, France.

出版信息

Pharmaceuticals (Basel). 2024 Nov 27;17(12):1602. doi: 10.3390/ph17121602.

DOI:10.3390/ph17121602
PMID:39770445
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11676857/
Abstract

The ATP-binding cassette (ABC) and solute carrier (SLC) transporters play pivotal roles in cellular transport mechanisms, influencing a wide range of physiological processes and impacting various medical conditions. Recent advancements in structural biology and computational modeling have provided significant insights into their function and regulation. This review provides an overview of the current knowledge of human ABC and SLC transporters, emphasizing their structural and functional relationships, transport mechanisms, and the contribution of computational approaches to their understanding. Current challenges and promising future research and methodological directions are also discussed.

摘要

ATP结合盒（ABC）转运蛋白和溶质载体（SLC）转运蛋白在细胞转运机制中发挥着关键作用，影响着广泛的生理过程，并对各种医学病症产生影响。结构生物学和计算建模方面的最新进展为它们的功能和调控提供了重要见解。本综述概述了目前关于人类ABC和SLC转运蛋白的知识，重点介绍了它们的结构和功能关系、转运机制以及计算方法对理解它们的贡献。还讨论了当前面临的挑战以及未来有前景的研究和方法学方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6086/11676857/e4d472bff1d5/pharmaceuticals-17-01602-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6086/11676857/0fdd26a707b8/pharmaceuticals-17-01602-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6086/11676857/ca77dca432ad/pharmaceuticals-17-01602-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6086/11676857/1f9901e8edb6/pharmaceuticals-17-01602-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6086/11676857/e4d472bff1d5/pharmaceuticals-17-01602-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6086/11676857/0fdd26a707b8/pharmaceuticals-17-01602-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6086/11676857/ca77dca432ad/pharmaceuticals-17-01602-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6086/11676857/1f9901e8edb6/pharmaceuticals-17-01602-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6086/11676857/e4d472bff1d5/pharmaceuticals-17-01602-g003.jpg

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