Department of Inorganic Chemistry, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland.
Department of Pharmacology, Medical University of Lublin, Radziwiłłowska 11, 20-080 Lublin, Poland.
Int J Mol Sci. 2024 Mar 23;25(7):3617. doi: 10.3390/ijms25073617.
Curcumin is a polyphenolic molecule derived from the rhizoma of L. This compound has been used for centuries due to its anti-inflammatory, antioxidant, and antimicrobial properties. These make it ideal for preventing and treating skin inflammation, premature skin ageing, psoriasis, and acne. Additionally, it exhibits antiviral, antimutagenic, and antifungal effects. Curcumin provides protection against skin damage caused by prolonged exposure to UVB radiation. It reduces wound healing times and improves collagen deposition. Moreover, it increases fibroblast and vascular density in wounds. This review summarizes the available information on the therapeutic effect of curcumin in treating skin diseases. The results suggest that curcumin may be an inexpensive, well-tolerated, and effective agent for treating skin diseases. However, larger clinical trials are needed to confirm these observations due to limitations in its in vivo use, such as low bioavailability after oral administration and metabolism.
姜黄素是一种从 姜黄根茎中提取的多酚分子。由于其具有抗炎、抗氧化和抗菌特性，这种化合物已经被使用了几个世纪。这使得它成为预防和治疗皮肤炎症、皮肤过早衰老、牛皮癣和痤疮的理想选择。此外，它还具有抗病毒、抗突变和抗真菌作用。姜黄素可防止皮肤因长期暴露于 UVB 辐射而受损。它可以减少伤口愈合时间并改善胶原蛋白沉积。此外，它还能增加伤口中的成纤维细胞和血管密度。这篇综述总结了姜黄素治疗皮肤病的治疗效果的现有信息。结果表明，姜黄素可能是一种廉价、耐受良好且有效的治疗皮肤病的药物。然而，由于其在体内使用的局限性，如口服后生物利用度低和代谢，还需要更大规模的临床试验来证实这些观察结果。
