Kim Hyungsup, Choi Mi Ran, Jeon Seong Ho, Jang Yongwoo, Yang Young Duk
Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
Laboratory Animal Research Center, Ajou University School of Medicine, Suwon 16499, Republic of Korea.
Int J Mol Sci. 2024 Feb 27;25(5):2756. doi: 10.3390/ijms25052756.
Psoriasis is a chronic inflammatory skin disease characterized by the rapid abnormal growth of skin cells in the epidermis, driven by an overactive immune system. Consequently, a complex interplay among epidermal cells, immune cells, and sensory neurons contributes to the development and progression of psoriasis. In these cellular contexts, various ion channels, such as acetylcholine receptors, TRP channels, Ca release-activated channels, chloride channels, and potassium channels, each serve specific functions to maintain the homeostasis of the skin. The dysregulation of ion channels plays a major role in the pathophysiology of psoriasis, affecting various aspects of epidermal cells, immune responses, and sensory neuron signaling. Impaired function of ion channels can lead to altered calcium signaling, inflammation, proliferation, and sensory signaling, all of which are central features of psoriasis. This overview summarizes the pathophysiological roles of ion channels in epidermal cells, immune cells, and sensory neurons during early and late psoriatic processes, thereby contributing to a deeper understanding of ion channel involvement in the interplay of psoriasis and making a crucial advance toward more precise and personalized approaches for psoriasis treatment.
银屑病是一种慢性炎症性皮肤病，其特征是在免疫系统过度活跃的驱动下，表皮中皮肤细胞快速异常生长。因此，表皮细胞、免疫细胞和感觉神经元之间的复杂相互作用促成了银屑病的发生和发展。在这些细胞环境中，各种离子通道，如乙酰胆碱受体、瞬时受体电位（TRP）通道、钙释放激活通道、氯离子通道和钾通道，各自发挥特定功能以维持皮肤的稳态。离子通道的失调在银屑病的病理生理学中起主要作用，影响表皮细胞、免疫反应和感觉神经元信号传导的各个方面。离子通道功能受损可导致钙信号传导改变、炎症、增殖和感觉信号传导异常，所有这些都是银屑病的核心特征。本综述总结了离子通道在银屑病早期和晚期过程中在表皮细胞、免疫细胞和感觉神经元中的病理生理作用，从而有助于更深入地理解离子通道在银屑病相互作用中的参与情况，并朝着更精确和个性化的银屑病治疗方法取得关键进展。
