Cintoni Marco, Palombaro Marta, Raoul Pauline, Chiloiro Giuditta, Romano Angela, Meldolesi Elisa, De Giacomo Flavia, Leonardi Elena, Egidi Gabriele, Grassi Futura, Pulcini Gabriele, Rinninella Emanuele, Capristo Esmeralda, Gasbarrini Antonio, Gambacorta Maria Antonietta, Mele Maria Cristina
UOC di Nutrizione Clinica, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy.
Centro di Ricerca e Formazione in Nutrizione Umana, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Nutrients. 2024 Dec 11;16(24):4277. doi: 10.3390/nu16244277.
Patients with rectal cancer (RC) are at risk of developing cancer-related cachexia, a complex metabolic syndrome that can negatively impact quality of life (QoL), treatment tolerance, and clinical response.
The aim of the study was to explore the possible associations of the novel European Organization for Research and Treatment of Cancer QoL Questionnaire-Cancer Cachexia (EORTC QLQ-CAX24) scores with body composition parameters and physical performance in patients with locally advanced RC (LARC).
This prospective observational study involved RC patients evaluated at the dedicated outpatient clinic of Clinical Nutrition at the Fondazione Policlinico Agostino Gemelli IRCCS. Patients with a confirmed diagnosis of LARC were enrolled between January and December 2023. The body composition parameters were measured using the preoperative computed tomography scan at the level of the third lumbar vertebra as well as using bioimpedance analysis before and after the radiotherapy treatment. QoL was measured by the EORTC QLQ-C30 and EORTC QLQ-CAX24 questionnaires.
A total of 56 RC patients were enrolled. Significant associations ( < 0.05) were found between EORTC QLQ-CAX24 values and the presence of cachexia, body composition, handgrip strength, and malnutrition diagnosis. Muscle mass was significatively also associated with EORTC QLQ-CAX24 results, suggesting a link between subjective perception of QoL and objectively measured body composition.
The EORTC CAX24 questionnaire can be an effective tool for monitoring changes in cachexia status during radiotherapy, enabling early detection of cachexia-related complications and timely intervention.
直肠癌（RC）患者有发生癌症相关恶病质的风险，这是一种复杂的代谢综合征，会对生活质量（QoL）、治疗耐受性和临床反应产生负面影响。
本研究旨在探讨新型欧洲癌症研究与治疗组织生活质量问卷 - 癌症恶病质（EORTC QLQ - CAX24）评分与局部晚期直肠癌（LARC）患者身体成分参数和身体机能之间的可能关联。
这项前瞻性观察性研究纳入了在罗马天主教圣心大学综合医院IRCCS临床营养专科门诊接受评估的RC患者。确诊为LARC的患者于2023年1月至12月入组。使用术前第三腰椎水平的计算机断层扫描以及放疗前后的生物电阻抗分析来测量身体成分参数。通过EORTC QLQ - C30和EORTC QLQ - CAX24问卷测量生活质量。
共纳入56例RC患者。发现EORTC QLQ - CAX24值与恶病质的存在、身体成分、握力和营养不良诊断之间存在显著关联（<0.05）。肌肉量也与EORTC QLQ - CAX24结果显著相关，表明生活质量的主观感受与客观测量的身体成分之间存在联系。
EORTC CAX24问卷可以成为监测放疗期间恶病质状态变化的有效工具，能够早期发现恶病质相关并发症并及时进行干预。
