Li Tianqi, Fili Mohammad, Mohammadiarvejeh Parvin, Dawson Alice, Hu Guiping, Willette Auriel A
Genetics and Genomics Program, Iowa State University, Ames, IA 50011, USA.
School of Industrial Engineering and Management, Oklahoma State University, Stillwater, OK 74078, USA.
Nutrients. 2024 Dec 13;16(24):4303. doi: 10.3390/nu16244303.
Coffee and tea are widely consumed beverages, but their long-term effects on cognitive function and aging remain largely unexplored. Lifestyle interventions, particularly dietary habits, offer promising strategies for enhancing cognitive performance and preventing cognitive decline.
This study utilized data from the UK Biobank cohort ( = 12,025) to examine the associations between filtered coffee, green tea, and standard tea consumption and neural network functional connectivity across seven resting-state networks. We focused on networks spanning prefrontal and occipital areas that are linked to complex cognitive and behavioral functions. Linear mixed models were used to assess the main effects of coffee and tea consumption, as well as their interactions with Apolipoprotein E (APOE) genetic risk-the strongest genetic risk factor for Alzheimer's disease (AD).
Higher filtered coffee consumption was associated with increased functional connectivity in several networks, including Motor Execution, Sensorimotor, Fronto-Cingular, and a Prefrontal + 'What' Pathway Network. Similarly, greater green tea intake was associated with enhanced connectivity in the Extrastriate Visual and Primary Visual Networks. In contrast, higher standard tea consumption was linked to reduced connectivity in networks such as Memory Consolidation, Motor Execution, Fronto-Cingular, and the "What" Pathway + Prefrontal Network. The APOE4 genotype and family history of AD influenced the relationship between coffee intake and connectivity in the Memory Consolidation Network. Additionally, the APOE4 genotype modified the association between standard tea consumption and connectivity in the Sensorimotor Network.
The distinct patterns of association between coffee, green tea, and standard tea consumption and resting-state brain activity may provide insights into AD-related brain changes. The APOE4 genotype, in particular, appears to play a significant role in modulating these relationships. These findings enhance our knowledge of how commonly consumed beverages may influence cognitive function and potentially AD risk among older adults.
咖啡和茶是广泛饮用的饮品，但其对认知功能和衰老的长期影响在很大程度上仍未得到充分研究。生活方式干预，尤其是饮食习惯，为提高认知表现和预防认知衰退提供了有前景的策略。
本研究利用英国生物银行队列（n = 12,025）的数据，来检验过滤咖啡、绿茶和标准茶的摄入量与七个静息态网络的神经网络功能连接之间的关联。我们重点关注跨越前额叶和枕叶区域的网络，这些区域与复杂的认知和行为功能相关。线性混合模型用于评估咖啡和茶摄入量的主要影响，以及它们与载脂蛋白E（APOE）基因风险（阿尔茨海默病（AD）最强的遗传风险因素）的相互作用。
较高的过滤咖啡摄入量与几个网络中功能连接的增加有关，包括运动执行、感觉运动、额扣带回以及一个前额叶 + “什么”通路网络。同样，较多的绿茶摄入量与纹外视觉和初级视觉网络中连接性的增强有关。相比之下，较高的标准茶摄入量与记忆巩固、运动执行、额扣带回以及“什么”通路 + 前额叶网络等网络中连接性的降低有关。APOE4基因型和AD家族史影响了记忆巩固网络中咖啡摄入量与连接性之间的关系。此外，APOE4基因型改变了标准茶摄入量与感觉运动网络中连接性之间的关联。
咖啡、绿茶和标准茶摄入量与静息态脑活动之间不同的关联模式可能为与AD相关的脑部变化提供见解。特别是APOE4基因型似乎在调节这些关系中起重要作用。这些发现增进了我们对常见饮品如何影响老年人认知功能以及潜在AD风险的了解。
