Atif Muhammad, Akhtar Hafsah, Imran Muhammad, Ullah Muhammad Zafar, Andaleeb Hina, Hussain Muhammad Asif
Chemistry Department, University of Education Lahore, Vehari Campus, Vehari 61100, Pakistan.
Interdisciplinary Research Centre in Biomedical Materials (IRCBM), COMSATS University Islamabad (CUI), Lahore Campus, Lahore 54000, Pakistan.
Polymers (Basel). 2024 Dec 11;16(24):3463. doi: 10.3390/polym16243463.
Recently, driven by a growing focus on environmental sustainability and cost-effectiveness, researchers have shown a keen interest in creating useful materials from bio-wastes, particularly for their potential applications in the biomedical field. Current research has been conducted on the impact of date seed powder (DSP) on hydroxyapatite (HA) formation, specifically in relation to the promotion of bone health and regeneration. HA is an essential component of bone tissue and plays a crucial role in maintaining bone strength and structure. Date seed (DS) was used in two forms i.e., grains and powder, with unmodified and modified surface chemistries. Prepared composites were tested in vitro by soaking them in simulated body fluid (SBF). X-ray Diffraction (XRD) and Fourier Transform Infra-Red (FTIR) confirmed HA formation in all soaked samples. Thermogravimetric analysis (TGA) results indicated an improvement in thermal stability after soaking, suggesting a higher concentration of HA. Unsoaked samples were observed to have higher heat flow than soaked samples. The high gel content (GCs) over 90% and low hydrophilicity (less than 5%) of DSP-based composites were proven to be beneficial in HA nucleation. Antibacterial activity showed that the addition of DS filler yielded superior results compared to the pristine sample. Additionally, the modified samples demonstrated better antibacterial results than the unmodified ones.
最近，在对环境可持续性和成本效益日益关注的推动下，研究人员对利用生物废料制造有用材料表现出浓厚兴趣，特别是其在生物医学领域的潜在应用。目前已经开展了关于椰枣籽粉（DSP）对羟基磷灰石（HA）形成的影响的研究，特别是在促进骨骼健康和再生方面。HA是骨组织的重要组成部分，在维持骨骼强度和结构方面起着关键作用。椰枣籽（DS）以两种形式使用，即颗粒和粉末，具有未改性和改性的表面化学性质。通过将制备的复合材料浸泡在模拟体液（SBF）中进行体外测试。X射线衍射（XRD）和傅里叶变换红外光谱（FTIR）证实了所有浸泡样品中均形成了HA。热重分析（TGA）结果表明浸泡后热稳定性有所提高，表明HA浓度更高。观察到未浸泡样品的热流比浸泡样品高。基于DSP的复合材料具有超过90%的高凝胶含量（GCs）和低于5%的低亲水性，被证明有利于HA成核。抗菌活性表明，与原始样品相比，添加DS填料产生了更好的结果。此外，改性样品的抗菌效果优于未改性样品。
