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具有维特里麦性质的3D打印丙烯酸化大豆油支架，由碲掺杂生物活性玻璃增强

3D-Printed Acrylated Soybean Oil Scaffolds with Vitrimeric Properties Reinforced by Tellurium-Doped Bioactive Glass.

作者信息

Bergoglio Matteo, Kriehuber Matthias, Sölle Bernhard, Rossegger Elisabeth, Schlögl Sandra, Najmi Ziba, Cochis Andrea, Ferla Federica, Miola Marta, Vernè Enrica, Sangermano Marco

机构信息

Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy.

Polymer Competence Center Leoben GmbH, Roseggerstrasse 12, 8700 Leoben, Austria.

出版信息

Polymers (Basel). 2024 Dec 23;16(24):3614. doi: 10.3390/polym16243614.

DOI:10.3390/polym16243614
PMID:39771465
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11679437/
Abstract

In this study, we present novel, vitrimeric and biobased scaffolds that are designed for hard tissue applications, composed of acrylated, epoxidized soybean oil (AESO) and reinforced with bioactive glass that is Tellurium doped (BG-Te) and BG-Te silanized, to tune the mechanical and antibacterial properties. The manufacture's method consisted of a DLP 3D-printing method, enabling precise resolution and the possibility to manufacture a hollow and complex structure. The resin formulation was optimized with a biobased, reactive diluent to adjust the viscosity for an optimal 3D-printing process. The in vitro biological evaluation of the 3D-printed scaffolds, combined with BG-Te and BG-Te-Sil, showed that the sample's surfaces remained safe for hBMSCs' attachment and proliferation. The number of that adhered to the BG-Te was 87% and 54% lower than on the pristine (control) and BG-Te-Sil, respectively, with the eradication of microbiofilm aggregates. This work highlights the effect of the vitrimeric polymer matrix and doped, bioactive glass in manufacturing biocompatible, biobased, and antibacterial scaffold used in hard tissue application.

摘要

在本研究中，我们展示了新型的、基于生物基的类玻璃高分子支架，其专为硬组织应用而设计，由丙烯酸化、环氧化大豆油（AESO）组成，并用掺杂碲的生物活性玻璃（BG-Te）和硅烷化的BG-Te增强，以调节机械性能和抗菌性能。制造方法包括数字光处理（DLP）3D打印方法，可实现精确分辨率，并有可能制造中空和复杂结构。树脂配方用生物基反应性稀释剂进行了优化，以调整粘度，实现最佳3D打印过程。对结合了BG-Te和BG-Te-Sil的3D打印支架进行的体外生物学评估表明，样品表面对人骨髓间充质干细胞（hBMSCs）的附着和增殖仍然安全。附着在BG-Te上的细胞数量分别比原始（对照）和BG-Te-Sil上的低87%和54%，同时消除了微生物膜聚集体。这项工作突出了类玻璃高分子聚合物基体以及掺杂的生物活性玻璃在制造用于硬组织应用的生物相容性、生物基和抗菌支架方面的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72b/11679437/34837ceb4ec2/polymers-16-03614-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72b/11679437/c2cbdc464aed/polymers-16-03614-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72b/11679437/5bcbea5c3060/polymers-16-03614-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72b/11679437/389668b5ba5c/polymers-16-03614-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72b/11679437/e9438ab7990f/polymers-16-03614-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72b/11679437/0041a2c087c2/polymers-16-03614-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72b/11679437/d358478f41fe/polymers-16-03614-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72b/11679437/9f3e0f238bc9/polymers-16-03614-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72b/11679437/1aa8a8d901a1/polymers-16-03614-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72b/11679437/2589314a7019/polymers-16-03614-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72b/11679437/28db9999b302/polymers-16-03614-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72b/11679437/7899295cff8e/polymers-16-03614-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72b/11679437/34837ceb4ec2/polymers-16-03614-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72b/11679437/c2cbdc464aed/polymers-16-03614-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72b/11679437/5bcbea5c3060/polymers-16-03614-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72b/11679437/389668b5ba5c/polymers-16-03614-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72b/11679437/e9438ab7990f/polymers-16-03614-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72b/11679437/0041a2c087c2/polymers-16-03614-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72b/11679437/d358478f41fe/polymers-16-03614-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72b/11679437/9f3e0f238bc9/polymers-16-03614-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72b/11679437/1aa8a8d901a1/polymers-16-03614-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72b/11679437/2589314a7019/polymers-16-03614-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72b/11679437/28db9999b302/polymers-16-03614-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72b/11679437/7899295cff8e/polymers-16-03614-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72b/11679437/34837ceb4ec2/polymers-16-03614-g012.jpg

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