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用于大麻二酚皮肤递送的脂质纳米颗粒制剂

Lipid Nanoparticle Formulations for the Skin Delivery of Cannabidiol.

作者信息

Calienni Maria Natalia, Scavone Mirian Ana, Sanguinetti Ana Paula, Corleto Merlina, Di Meglio Magalí Rocío, Raies Pablo, Cristos Diego Sebastián, Maffia Paulo César, Montanari Jorge

机构信息

Universidad Nacional de Hurlingham (UNAHUR), Secretaría de Investigación, Laboratorio de Nanosistemas de Aplicación Biotecnológica (LANSAB), Hurlingham 1688, Buenos Aires, Argentina.

Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad Autónoma de Buenos Aires 1425, Argentina.

出版信息

Pharmaceutics. 2024 Nov 21;16(12):1490. doi: 10.3390/pharmaceutics16121490.

DOI:10.3390/pharmaceutics16121490
PMID:39771468
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11676254/
Abstract

The aims of this work were to formulate cannabidiol in different lipid carriers for skin delivery after topical application and to study their stability, interaction with the skin, and antibacterial activity. Solid lipid nanoparticles and nanostructured lipid carriers loaded with cannabidiol were prepared and characterized in terms of their physicochemical properties, colloidal stability, protection of the antioxidant capacity of cannabidiol, as well as their retention over time. Skin penetration was assessed using an in vitro model with human skin. The antibacterial activity was tested against and compared to free cannabidiol. Three nanoformulations exhibited the best size and reproducibility values and were selected for further studies. The formulations were stable, protected the active ingredient, succeeded in delivering it to deep skin layers, and demonstrated antibacterial activity. These cannabidiol nanoformulations show potential for use in skin diseases and conditions, as they protect the active ingredient, enhance its delivery to the skin, and exhibit antibacterial effects.

摘要

这项工作的目的是将大麻二酚制成不同的脂质载体，用于局部应用后的皮肤给药，并研究它们的稳定性、与皮肤的相互作用以及抗菌活性。制备了负载大麻二酚的固体脂质纳米粒和纳米结构脂质载体，并对其物理化学性质、胶体稳定性、大麻二酚抗氧化能力的保护以及随时间的保留情况进行了表征。使用具有人类皮肤的体外模型评估皮肤渗透性。测试了抗菌活性，并与游离大麻二酚进行比较。三种纳米制剂表现出最佳的尺寸和重现性值，并被选作进一步研究。这些制剂稳定，保护活性成分，成功地将其递送至皮肤深层，并显示出抗菌活性。这些大麻二酚纳米制剂在皮肤疾病和病症中显示出应用潜力，因为它们保护活性成分，增强其向皮肤的递送，并表现出抗菌作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f0b/11676254/243acf3979ab/pharmaceutics-16-01490-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f0b/11676254/4db15ee59d58/pharmaceutics-16-01490-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f0b/11676254/b3fb17c0ae7b/pharmaceutics-16-01490-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f0b/11676254/c4e9a3172268/pharmaceutics-16-01490-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f0b/11676254/e202e70ab1e3/pharmaceutics-16-01490-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f0b/11676254/e014be6882ee/pharmaceutics-16-01490-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f0b/11676254/d3f2b8a8668c/pharmaceutics-16-01490-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f0b/11676254/e210822d4cdc/pharmaceutics-16-01490-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f0b/11676254/d7347f2c0ee1/pharmaceutics-16-01490-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f0b/11676254/243acf3979ab/pharmaceutics-16-01490-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f0b/11676254/4db15ee59d58/pharmaceutics-16-01490-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f0b/11676254/b3fb17c0ae7b/pharmaceutics-16-01490-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f0b/11676254/c4e9a3172268/pharmaceutics-16-01490-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f0b/11676254/e202e70ab1e3/pharmaceutics-16-01490-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f0b/11676254/e014be6882ee/pharmaceutics-16-01490-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f0b/11676254/d3f2b8a8668c/pharmaceutics-16-01490-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f0b/11676254/e210822d4cdc/pharmaceutics-16-01490-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f0b/11676254/d7347f2c0ee1/pharmaceutics-16-01490-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f0b/11676254/243acf3979ab/pharmaceutics-16-01490-g009.jpg

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