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用于疾病治疗的水凝胶微针给药系统的研究进展

Advances in Research of Hydrogel Microneedle-Based Delivery Systems for Disease Treatment.

作者信息

Cao Juan, Wu Bo, Yuan Ping, Liu Yeqi, Hu Cheng

机构信息

School of Fashion and Design Art, Sichuan Normal University, Chengdu 610066, China.

School of Mechanical Engineering, Sichuan University, Chengdu 610065, China.

出版信息

Pharmaceutics. 2024 Dec 9;16(12):1571. doi: 10.3390/pharmaceutics16121571.

DOI:10.3390/pharmaceutics16121571
PMID:39771550
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11676655/
Abstract

Microneedles (MNs), composed of multiple micron-scale needle-like structures attached to a base, offer a minimally invasive approach for transdermal drug delivery by penetrating the stratum corneum and delivering therapeutic agents directly to the epidermis or dermis. Hydrogel microneedles (HMNs) stand out among various MN types due to their excellent biocompatibility, high drug-loading capacity, and tunable drug-release properties. This review systematically examines the matrix materials and fabrication methods of HMN systems, highlighting advancements in natural and synthetic polymers, and explores their applications in treating conditions such as wound healing, hair loss, cardiovascular diseases, and cancer. Furthermore, the potential of HMNs for disease diagnostics is discussed. The review identifies key challenges, including limited mechanical strength, drug-loading efficiency, and lack of standardization, while proposing strategies to overcome these issues. With the integration of intelligent design and enhanced control over drug dosage and safety, HMNs are poised to revolutionize transdermal drug delivery and expand their applications in personalized medicine.

摘要

微针（MNs）由附着在基底上的多个微米级针状结构组成，通过穿透角质层并将治疗剂直接递送至表皮或真皮，为透皮给药提供了一种微创方法。水凝胶微针（HMNs）在各种微针类型中脱颖而出，因为它们具有出色的生物相容性、高载药能力和可调节的药物释放特性。本文系统地研究了HMN系统的基质材料和制备方法，突出了天然和合成聚合物方面的进展，并探讨了它们在治疗伤口愈合、脱发、心血管疾病和癌症等病症中的应用。此外，还讨论了HMNs在疾病诊断方面的潜力。该综述确定了关键挑战，包括机械强度有限、载药效率低和缺乏标准化，同时提出了克服这些问题的策略。随着智能设计的整合以及对药物剂量和安全性的更好控制，HMNs有望彻底改变透皮给药，并扩大其在个性化医疗中的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/124d/11676655/0f9c1cb77159/pharmaceutics-16-01571-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/124d/11676655/edca721c4335/pharmaceutics-16-01571-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/124d/11676655/52f8ae24225d/pharmaceutics-16-01571-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/124d/11676655/331347e350cf/pharmaceutics-16-01571-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/124d/11676655/dc8d8f27209d/pharmaceutics-16-01571-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/124d/11676655/6fc5e95b4208/pharmaceutics-16-01571-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/124d/11676655/0225cec606e0/pharmaceutics-16-01571-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/124d/11676655/61f726858bf0/pharmaceutics-16-01571-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/124d/11676655/d3f49a7e6bcb/pharmaceutics-16-01571-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/124d/11676655/96ae00037647/pharmaceutics-16-01571-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/124d/11676655/0f9c1cb77159/pharmaceutics-16-01571-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/124d/11676655/edca721c4335/pharmaceutics-16-01571-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/124d/11676655/d4db665ef86a/pharmaceutics-16-01571-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/124d/11676655/52f8ae24225d/pharmaceutics-16-01571-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/124d/11676655/331347e350cf/pharmaceutics-16-01571-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/124d/11676655/dc8d8f27209d/pharmaceutics-16-01571-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/124d/11676655/6fc5e95b4208/pharmaceutics-16-01571-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/124d/11676655/0225cec606e0/pharmaceutics-16-01571-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/124d/11676655/61f726858bf0/pharmaceutics-16-01571-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/124d/11676655/d3f49a7e6bcb/pharmaceutics-16-01571-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/124d/11676655/96ae00037647/pharmaceutics-16-01571-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/124d/11676655/0f9c1cb77159/pharmaceutics-16-01571-g011.jpg

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