Department of Andrology, Nanjing Drum Tower Hospital, Clinical Medical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210096, China.
Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, 210008, China.
Small. 2024 Nov;20(45):e2404850. doi: 10.1002/smll.202404850. Epub 2024 Jul 28.
Several natural Chinese herbal medicines have demonstrated considerable potential in facilitating wound healing, while the primary concern remains centered around optimizing formulation and structure to maximize their efficacy. To address this, a natural microneedles drug delivery system is proposed that harnesses gelatinized starch and key Chinese herbal ingredients-aloe vera and berberine. After gelatinized and aged in a well-designed mold, the starch-based microneedles are fabricated with suitable mechanical strength to load components. The resulting Chinese herbal hydrogel microneedles, enriched with integrated berberine and aloe, exhibit antibacterial, anti-inflammatory, and fibroblast growth-promoting properties, thereby facilitating wound healing in the whole process. In vivo experimental results underscore the notable achievements of the microneedles in early-stage antibacterial effects and subsequent tissue reconstruction, contributing significantly to the overall wound healing process. These results emphasize the advantageous combination of traditional Chinese medicine with microneedles, presenting a novel strategy for wound repair and opening new avenues for the application of traditional Chinese medicine.
几种天然中草药在促进伤口愈合方面显示出了相当大的潜力，而主要关注点仍然集中在优化配方和结构以最大限度地提高它们的功效上。为了解决这个问题，提出了一种利用明胶化淀粉和关键中草药成分——芦荟和黄连素的天然微针药物传递系统。经过明胶化和在精心设计的模具中老化，基于淀粉的微针具有合适的机械强度来加载组件。由此产生的富含集成黄连素和芦荟的中草药水凝胶微针具有抗菌、抗炎和促进成纤维细胞生长的特性，从而促进整个愈合过程中的伤口愈合。体内实验结果强调了微针在早期抗菌效果和随后的组织重建方面的显著成就，为整体伤口愈合过程做出了重要贡献。这些结果强调了中药与微针的优势结合，为伤口修复提供了一种新策略，为中药的应用开辟了新途径。
