Department of Dermatology, University of Maryland School of Medicine, Baltimore, MD, USA.
Department of Dermatology, Veterans Affairs Medical Center, New York, NY, USA.
Clin Exp Dermatol. 2023 Mar 22;48(4):310-318. doi: 10.1093/ced/llac108.
Psoriasis is a chronic immune-mediated condition that affects the skin and joints, with current treatments still unable to offer a cure and long-term use of treatments posing health risks. Understanding the pathogenesis of the disease has helped identify new targets that have allowed for the expansion of the therapeutic arsenal. Extracellular vesicles (EVs) have recently emerged as pathophysiological mediators of psoriasis, and there have been increasing reports of EVs as potential biomarkers and therapeutics. Given their innate role as natural vehicles for cell-to-cell communication, EVs have vast potential in their ability to determine disease status based on EV-specific cargo as well as act as therapeutics because of their anti-inflammatory properties and potential for enhancement. In this review we summarize the role of EVs in the pathogenesis of psoriasis and discuss EVs as both diagnostic and therapeutic agents.
银屑病是一种慢性免疫介导性疾病，影响皮肤和关节，目前的治疗方法仍无法治愈，而且长期使用治疗方法会带来健康风险。对疾病发病机制的理解有助于确定新的靶点，从而扩大治疗武器库。细胞外囊泡（EVs）最近被认为是银屑病的病理生理介质，并且越来越多的报道称 EVs 是潜在的生物标志物和治疗药物。鉴于它们作为细胞间通讯天然载体的固有作用，EVs 具有巨大的潜力，可以根据 EV 特异性货物来确定疾病状态，并因其抗炎特性和增强潜力而作为治疗药物。在这篇综述中，我们总结了 EVs 在银屑病发病机制中的作用，并讨论了 EVs 作为诊断和治疗药物的双重作用。
