Pan Danjie, Liu Jiayang, Huang Xuan, Wang Songna, Kuerban Kudelaidi, Yan Yan, Zhu Yi Zhun, Ye Li
Laboratory of Drug Discovery from Natural Resources and Industrialization, School of Pharmacy, Macau University of Science and Technology, Macau 999078, China.
Department of Biological Medicines, School of Pharmacy, Fudan University, Shanghai 201203, China.
Vaccines (Basel). 2024 Nov 28;12(12):1341. doi: 10.3390/vaccines12121341.
Tumor vaccine is a promising immunotherapy for solid tumors. Therapeutic tumor vaccines aim at inducing tumor regression, establishing durable antitumor memory, and avoiding non-specific or adverse reactions. However, tumor-induced immune suppression and immune resistance pose challenges to achieving this goal. In this article, we review multiple challenges currently faced in the development of therapeutic tumor vaccines, with a particular focus on anonymous antigen vaccines in situ as a new direction. We summarize the research progress in this area, aiming to provide a reference for future studies on tumor vaccines.
肿瘤疫苗是一种有前途的实体瘤免疫疗法。治疗性肿瘤疫苗旨在诱导肿瘤消退、建立持久的抗肿瘤记忆并避免非特异性或不良反应。然而，肿瘤诱导的免疫抑制和免疫抗性对实现这一目标构成了挑战。在本文中，我们综述了治疗性肿瘤疫苗开发目前面临的多重挑战，特别关注原位匿名抗原疫苗这一新方向。我们总结了该领域的研究进展，旨在为未来肿瘤疫苗的研究提供参考。
