Zhou Wenhao, Lu Xiaojun, Tian Feng, Luo Qianming, Zhou Weihang, Yang Siyuan, Li Wenxuan, Yang Yongjun, Shi Minfeng, Zhou Tie
Department of Urology, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China.
Department of Urology, Shanghai Eighth People's Hospital, Shanghai 200235, China.
Vaccines (Basel). 2024 Dec 9;12(12):1384. doi: 10.3390/vaccines12121384.
Prostate cancer is a prevalent cancer in elderly men, and immunotherapy has emerged as a promising treatment approach in recent years. The aim of immunotherapy is to stimulate the body's immune system to target and destroy cancer cells. Cancer vaccines that are highly specific, safe, and capable of creating long-lasting immune responses are a key focus in cancer immunotherapy research. Despite progress in clinical trials showing positive results, the practical use of cancer vaccines still encounters various obstacles. The complexity of the immune microenvironment and variations in the immune systems of individual patients have hindered the progress of research on prostate cancer vaccines. This review examines the history and mechanisms of cancer vaccines, summarizes recent clinical research findings, and explores future directions in the development of prostate cancer vaccines.
前列腺癌是老年男性中一种常见的癌症，近年来免疫疗法已成为一种有前景的治疗方法。免疫疗法的目的是刺激人体免疫系统靶向并摧毁癌细胞。高度特异性、安全且能够产生持久免疫反应的癌症疫苗是癌症免疫疗法研究的一个关键重点。尽管临床试验取得了积极成果，但癌症疫苗的实际应用仍面临各种障碍。免疫微环境的复杂性以及个体患者免疫系统的差异阻碍了前列腺癌疫苗的研究进展。本文综述了癌症疫苗的历史和作用机制，总结了近期的临床研究结果，并探讨了前列腺癌疫苗未来的发展方向。
