Gooding Diane Carol, Van Hulle Carol A, Zuelsdorff Megan, Lewis Jordan P, Carter Fabu P, Salazar Hector, Bouges Shenikqua, James Taryn T, Gee Alexander, Gleason Carey E
Department of Psychology, UW-Madison, Madison, WI, USA.
Department of Psychiatry, Schools of Medicine and Public Health, UW-Madison, Madison, WI USA.
J Alzheimers Dis. 2025 Feb;103(3):865-878. doi: 10.1177/13872877241307255. Epub 2025 Jan 8.
Past research suggests that ethnoracialized groups differ in their willingness to engage in preclinical Alzheimer's disease (AD) research overall. Studies indicated that participation willingness was affected by attitudes toward research and perceived invasiveness of biomarker collection techniques. However, comparative quantitative studies are few, and minoritized groups are under-included.
In a cross-sectional online survey, we sought to explore community-based adults' willingness to engage in preclinical AD biomarker testing, comparing their attitudes about research and different types of biomarker procedures.
We conducted an online survey with a diverse group of participants. African American (AA), American Indian/Alaska Native (AI/AN), Latinx (LTX), and Non-Hispanic White (NHW) adults aged 26-90 were asked about their research attitudes, biomarkers, and willingness to participate in specific biomarker test procedures (i.e., brain imaging via PET scanning, blood draws, and cerebrospinal fluid collection by lumbar puncture). We also assessed participants' perceived safety, burden, and distress for each of the three biomarker collection methods. To understand the association between research willingness and ethnoracial identity, we ran linear regression models for each procedure, adjusting for age, gender, educational attainment, and attitudes toward research.
The AA group expressed greater willingness to engage in biomarker testing involving blood draws than the NHW group. The AI/AN group was significantly less willing to undergo lumbar puncture than the NHW group; this difference remained after adjusting for various sociodemographic factors and research attitudes.
Respondents' willingness to engage in preclinical AD biomarker research was affected by their perceptions about the testing collection procedure.
以往研究表明，不同种族群体参与临床前阿尔茨海默病（AD）研究的意愿总体上存在差异。研究表明，参与意愿受对研究的态度以及生物标志物采集技术的感知侵入性影响。然而，比较定量研究较少，少数群体参与度不足。
在一项横断面在线调查中，我们试图探讨社区成年人参与临床前AD生物标志物检测的意愿，比较他们对研究和不同类型生物标志物检测程序的态度。
我们对不同群体的参与者进行了在线调查。询问了年龄在26 - 90岁的非裔美国人（AA）、美国印第安人/阿拉斯加原住民（AI/AN）、拉丁裔（LTX）和非西班牙裔白人（NHW）成年人关于他们的研究态度、生物标志物以及参与特定生物标志物检测程序（即通过PET扫描进行脑成像、抽血和腰椎穿刺采集脑脊液）的意愿。我们还评估了参与者对三种生物标志物采集方法中每一种的感知安全性、负担和痛苦程度。为了解研究意愿与种族身份之间的关联，我们对每个程序运行线性回归模型，并对年龄、性别、教育程度和对研究的态度进行了调整。
非裔美国人组比非西班牙裔白人组更愿意参与涉及抽血的生物标志物检测。美国印第安人/阿拉斯加原住民组比非西班牙裔白人组明显更不愿意接受腰椎穿刺；在调整各种社会人口统计学因素和研究态度后，这种差异仍然存在。
受访者参与临床前AD生物标志物研究的意愿受其对检测采集程序的认知影响。
