Salazar Christian R, Hoang Dan, Gillen Daniel L, Grill Joshua D
UC Irvine Institute for Memory Impairments and Neurological Disorders University of California, Irvine Irvine California USA.
Department of Statistics University of California, Irvine Irvine California USA.
Alzheimers Dement (N Y). 2020 May 8;6(1):e12023. doi: 10.1002/trc2.12023. eCollection 2020.
We sought to examine the association of race/ethnicity with willingness to engage in studies that involve procedures typical of Alzheimer's disease (AD) clinical trials and determine whether any observed differences could be explained by research attitudes.
We studied 2749 adults aged ≥50 years who enrolled in a community-based recruitment registry.
Compared to non-Hispanic (NH) whites (n = 2393, 87%), Hispanics (n = 191, 7%), NH Asians (n = 129, 5%) and NH blacks (n = 36, 1%) were 44%, 46%, and 64% less willing, respectively, to be contacted for studies that have requirements typical of AD prevention trials, namely: cognitive testing, brain imaging, blood draws, and investigational medications. Mediation by research attitudes was explored, but did not explain the observed differences.
Our findings suggest that ethnoracial minorities are less willing to engage in studies that are typical of AD prevention trials. Future work should focus on understanding the factors that drive these differences.
我们试图研究种族/民族与参与涉及阿尔茨海默病（AD）临床试验典型程序的研究的意愿之间的关联，并确定观察到的任何差异是否可以通过研究态度来解释。
我们研究了2749名年龄≥50岁且登记参加社区招募登记处的成年人。
与非西班牙裔（NH）白人（n = 2393，87%）相比，西班牙裔（n = 191，7%）、NH亚裔（n = 129，5%）和NH黑人（n = 36，1%）分别有44%、46%和64%的人不太愿意被联系参与具有AD预防试验典型要求的研究，即：认知测试、脑部成像、抽血和研究用药物。我们探讨了研究态度的中介作用，但它并不能解释观察到的差异。
我们的研究结果表明，少数族裔不太愿意参与AD预防试验典型的研究。未来的工作应侧重于了解导致这些差异的因素。
