[非那西泮对小型猪（一种新型实验动物）的胚胎趋向性作用]
[Embryotropic action of phenazepam in mini pigs, a new species of experimental animals].
作者信息
Liubimov B I, Smol'nikova N M, Strekalova S N, Boĭko S S, Iavorskiĭ A N
出版信息
Biull Eksp Biol Med. 1979 Nov;88(11):557-60.
PMID:540144
Abstract
It has been established in experiments on mini pigs of Siberian origin that phenazepam given at a dose of 1 mg/kg per os during organogenesis has no embryotoxic or teratogenic action. The drug content in the blood of pregnant animals was determined simultaneously. A conclusion is drawn about perspectiveness of using mini pigs for testing embryotoxic activity of drugs.
摘要
在对西伯利亚小型猪进行的实验中已证实，在器官形成期经口给予剂量为1毫克/千克的芬那西泮没有胚胎毒性或致畸作用。同时测定了怀孕动物血液中的药物含量。得出了关于使用小型猪来测试药物胚胎毒性活性的前景的结论。
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