Burke R E, Reches A, Traub M M, Ilson J, Swash M, Fahn S
Ann Neurol. 1985 Feb;17(2):200-2. doi: 10.1002/ana.410170217.
Four patients suffered acute dystonic reactions caused by tetrabenazine. Because dystonic reactions have previously been reported only after dopamine receptor blockade and not with dopamine depletion, it is likely that the ability of tetrabenazine to induce acute dystonia is due to its dopamine receptor blocking properties. Because tetrabenazine can induce acute dystonia even when combined with alpha-methyl-p-tyrosine, presynaptic dopamine stores may not be necessary for these reactions to occur.
4名患者出现了由丁苯那嗪引起的急性肌张力障碍反应。由于此前仅在多巴胺受体阻断后而非多巴胺耗竭后报道过肌张力障碍反应，因此丁苯那嗪诱发急性肌张力障碍的能力可能归因于其多巴胺受体阻断特性。因为即使与α-甲基-对-酪氨酸联合使用，丁苯那嗪仍可诱发急性肌张力障碍，所以这些反应的发生可能不需要突触前多巴胺储备。
