He Haodong, Yang Jingjie, Zhou Yan, Zheng Xinyan, Chen Lihan, Mao Zhujun, Liao Chuyuan, Li Tongtong, Liu Haoran, Zhou Gang, Li Houdong, Yuan Chengfu
Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, 443002, China.
College of Basic Medical Science, China Three Gorges University, Yichang, 443002, China.
Anticancer Agents Med Chem. 2025;25(8):533-543. doi: 10.2174/0118715206359325241119075640.
Long non-coding RNA (lncRNA) is a type of non-coding RNA distinguished by a length exceeding 200 nucleotides. Recent studies indicated that lncRNAs participate in various biological processes, such as chromatin remodeling, transcriptional and post-transcriptional regulation, and the modulation of cell proliferation, death, and differentiation, hence influencing gene expression and cellular function. ADAMTS9-AS1, an antisense long non-coding RNA situated on human chromosome 3p14.1, has garnered significant interest due to its pivotal involvement in the advancement and spread of diverse malignant tumors. ADAMTS9-AS1 functions as a competitive endogenous RNA (ceRNA) that interacts with multiple microRNAs (miRNAs) and plays a crucial role in regulating gene expression and cellular functions by modulating essential signaling pathways, including PI3K/AKT/mTOR, Wnt/β-catenin, and Ras/MAPK pathways. Dysregulation of this factor has been linked to tumor development, migration, invasion, and resistance to apoptotic mechanisms, including as iron-induced apoptosis, underscoring its intricate function in cancer pathology. While current research has clarified certain pathways involved in cancer formation, additional clinical and investigations are necessary to enhance comprehension of its specific involvement across various cancer types. This review encapsulates the recent discoveries on the correlation of ADAMTS9-AS1 with numerous malignancies, clarifying its molecular mechanisms and its prospective role as a therapeutic target in oncology. Furthermore, it identifies ADAMTS9-AS1 as a potential early diagnostic biomarker and therapeutic target, offering novel opportunities for targeted intervention in oncology.
长链非编码RNA（lncRNA）是一类长度超过200个核苷酸的非编码RNA。最近的研究表明，lncRNAs参与各种生物学过程，如染色质重塑、转录和转录后调控，以及细胞增殖、死亡和分化的调节，从而影响基因表达和细胞功能。ADAMTS9-AS1是一种位于人类染色体3p14.1上的反义长链非编码RNA，因其在多种恶性肿瘤的进展和扩散中起关键作用而备受关注。ADAMTS9-AS1作为一种竞争性内源性RNA（ceRNA），与多种微小RNA（miRNA）相互作用，并通过调节包括PI3K/AKT/mTOR、Wnt/β-连环蛋白和Ras/MAPK途径在内的关键信号通路，在调节基因表达和细胞功能方面发挥关键作用。该因子的失调与肿瘤发展、迁移、侵袭以及对凋亡机制的抵抗有关，包括铁诱导的凋亡，这突出了其在癌症病理学中的复杂功能。虽然目前的研究已经阐明了某些与癌症形成相关的途径，但仍需要更多的临床和研究来加深对其在各种癌症类型中具体作用的理解。这篇综述总结了关于ADAMTS9-AS1与多种恶性肿瘤相关性的最新发现，阐明了其分子机制及其作为肿瘤学治疗靶点的潜在作用。此外，它将ADAMTS9-AS1确定为一种潜在的早期诊断生物标志物和治疗靶点，为肿瘤学中的靶向干预提供了新的机会。
