Robinson H N, Morison W L, Hood A F
Arch Dermatol. 1985 Apr;121(4):522-4.
Chronic photosensitivity associated with hydrochlorothiazide ingestion occurred in four patients. These patients developed a debilitating photosensitivity that persisted for months to years even after they stopped taking the diuretic. Their age range was 44 to 66 years. Phototesting with ultraviolet B (UV-B) and ultraviolet A (UV-A) radiation revealed decreased minimal erythemal doses for one or both wave bands in all patients tested. Histologic examination of skin biopsy specimens from the patients' UV-B and UV-A test sites and lesional skin revealed an acute eczematous dermatitis. Treatment with methoxsalen and UV-A radiation successfully cleared the photosensitive eruption in the patients.
四名患者出现了与服用氢氯噻嗪相关的慢性光敏反应。这些患者出现了使人衰弱的光敏反应，即使在停止服用利尿剂后，这种反应仍持续数月至数年。他们的年龄在44岁至66岁之间。用紫外线B（UV-B）和紫外线A（UV-A）辐射进行光测试发现，所有接受测试的患者中，一个或两个波段的最小红斑剂量均降低。对患者UV-B和UV-A测试部位以及皮损处皮肤活检标本进行组织学检查，显示为急性湿疹性皮炎。用甲氧沙林和UV-A辐射治疗成功清除了患者的光敏性皮疹。
